CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042746
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ribonuclease H1 
Protein Synonyms/Alias
  
Gene Name
 RNH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20LCGIVASKASLRELAubiquitination[1, 2, 3, 4, 5]
32ELALGSNKLGDVGMAubiquitination[4]
77LCRVLRAKESLKELSubiquitination[1, 2, 4]
81LRAKESLKELSLAGNubiquitination[1, 2, 3, 4, 5, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
ESCGVTSDNC RDLCGIVASK ASLRELALGS NKLGDVGMAE LCPGLLHPSS RLRTLWIWEC 60
GITAKGCGDL CRVLRAKESL KELSLAGNEL GDEGARLLCE TLLEPGCQLE SLWVKSCSFT 120
AACCSHFSSV LAQNRFLLEL QISNNRLEDA GVRELCQGLG QPGSVLRVLW LADCDVSDSS 180
CSSLAATLLA NHSLRELDLS NNCLGDAGIL QLVESVRQPG CLLEQLVYVH ALGGWCGQGC 240
PGRKAGVGED TGPCLPSGLC AACTTFTGLR RWRTGCRPWR RTSHP 285 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA. 
Interpro
 IPR003590; Leu-rich_rpt_RNase_inh_sub-typ. 
Pfam
  
SMART
 SM00368; LRR_RI 
PROSITE
  
PRINTS