UniProt Accession

 INO1_HUMAN; Q9NPH2; B3KRT1; G5E9U0; Q6NXT5; Q7Z525; Q9BT65; Q9H2Y2; Q9NSU0; Q9NVW7 

Genbank Protein ID

 AF207640; AF220530; AF220259; AF220250; AF220251; AF220252; AF220253; AF220254; AF220255; AF220256; AF220257; AF220258; AF086921; AK001325; AK021526; AK092179; AL137749; AC008397; CH471106; CH471106; BC004320; BC018952; BC066902 

Genbank Nucleotide ID

 AAG35698.1; AAF26444.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAP97151.1; BAA91626.1; BAB13837.1; BAG52493.1; CAB70904.1; EAW84703.1; EAW84705.1; AAH04320.1; AAH18952.1; AAH66902.1 

Protein Name

 Inositol-3-phosphate synthase 1 

Protein Synonyms/Alias

 IPS 1; Myo-inositol 1-phosphate synthase; MI-1-P synthase; MIP synthase; hIPS; Myo-inositol 1-phosphate synthase A1; hINO1 

Gene Name

 ISYNA1 

Gene Synonyms/Alias

 INO1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	SREGGVLKVHPTSTR	ubiquitination	[1]
155	AEAMRRAKVLDWGLQ	ubiquitination	[2, 3]
222	RSSAGLDKVIVLWTA	ubiquitination	[1, 2, 3]
305	FVGGDDFKSGQTKVK	ubiquitination	[1]
310	DFKSGQTKVKSVLVD	ubiquitination	[1]
312	KSGQTKVKSVLVDFL	ubiquitination	[1, 2, 3]
393	VPYVGDSKRALDEYT	ubiquitination	[1]
530	ATYPMLNKKGPVPAA	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis; Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004512; F:inositol-3-phosphate synthase activity; TAS:Reactome.
 GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
 GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR002587; Myo-inos-1-P_Synthase.
 IPR013021; Myo-inos-1-P_Synthase_GAPDH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01658; Inos-1-P_synth
 PF07994; NAD_binding_5 

SMART

  

PROSITE

  

PRINTS