| Tag | Content |
|---|
| CPLM ID | CPLM-001374 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Claudin-2 |
Protein Synonyms/Alias | |
Gene Name | Cldn2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 216 | PRSAQQPKAKSEFNS | ubiquitination | [1] | | 218 | SAQQPKAKSEFNSYS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. |
Sequence Annotation | REGION 229 230 Interactions with TJP1, TJP2 and TJP3 (By
DISULFID 54 64 By similarity.
CROSSLNK 218 218 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Cell junction; Cell membrane; Complete proteome; Disulfide bond; Isopeptide bond; Membrane; Reference proteome; Tight junction; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 230 AA |
Protein Sequence | MASLGVQLVG YILGLLGLLG TSIAMLLPNW RTSSYVGASI VTAVGFSKGL WMECATHSTG 60
ITQCDIYSTL LGLPADIQAA QAMMVTSSAM SSLACIISVV GMRCTVFCQD SRAKDRVAVV 120
GGVFFILGGI LGFIPVAWNL HGILRDFYSP LVPDSMKFEI GEALYLGIIS ALFSLVAGVI 180
LCFSCSPQGN RTNYYDGYQA QPLATRSSPR SAQQPKAKSE FNSYSLTGYV 230 |
Gene Ontology | GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005923; C:tight junction; IDA:UniProtKB. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0016338; P:calcium-independent cell-cell adhesion; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |