CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008280
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab GDP dissociation inhibitor beta 
Protein Synonyms/Alias
 Rab GDI beta; GDI-3; Guanosine diphosphate dissociation inhibitor 2; GDI-2 
Gene Name
 Gdi2 
Gene Synonyms/Alias
 Gdi3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
112IEGSFVYKGGKIYKVacetylation[1]
142FEKRRFRKFLVYVANacetylation[1]
164TFEGVDPKKTSMRDVacetylation[1]
174SMRDVYKKFDLGQDVacetylation[1]
269NGKVVGVKSEGEIARacetylation[1]
360VSTTVETKEPEKEIRubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 112 112 N6-acetyllysine (By similarity).
 MOD_RES 269 269 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; GTPase activation; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDQNPYYG GESASITPLE DLYKRFKLPG 60
QPPASMGRGR DWNVDLIPKF LMANGQLVKM LLFTEVTRYM DFKVIEGSFV YKGGKIYKVP 120
STEAEALASS LMGLFEKRRF RKFLVYVANF DEKDPRTFEG VDPKKTSMRD VYKKFDLGQD 180
VIDFTGHSLA LYRTDDYLDQ PCCETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR 240
LSAIYGGTYM LNKPIEEIIV QNGKVVGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV 300
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI AIVSTTVETK 360
EPEKEIRPAL ELLEPIEQKF VSISDLFVPK DLGTDSQIFI SRAYDATTHF ETTCDDIKDI 420
YKRMTGSEFD FEEMKRKKND IYGED 445 
Gene Ontology
 GO:0005829; C:cytosol; TAS:RGD.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005093; F:Rab GDP-dissociation inhibitor activity; IDA:RGD.
 GO:0031267; F:small GTPase binding; IDA:RGD.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0015031; P:protein transport; TAS:RGD.
 GO:0016192; P:vesicle-mediated transport; IEP:RGD. 
Interpro
 IPR018203; GDP_dissociation_inhibitor.
 IPR000806; RabGDI. 
Pfam
 PF00996; GDI 
SMART
  
PROSITE
  
PRINTS
 PR00892; RABGDI.
 PR00891; RABGDIREP.