CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021702
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Junctophilin-1 
Protein Synonyms/Alias
 JP-1; Junctophilin type 1 
Gene Name
 JPH1 
Gene Synonyms/Alias
 JP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91GEWSHGFKGRYGVRQubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. 
Sequence Annotation
 REPEAT 14 36 MORN 1.
 REPEAT 38 59 MORN 2.
 REPEAT 60 82 MORN 3.
 REPEAT 106 128 MORN 4.
 REPEAT 129 151 MORN 5.
 REPEAT 281 303 MORN 6.
 REPEAT 304 326 MORN 7.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 216 216 Phosphoserine.
 MOD_RES 220 220 Phosphoserine.
 MOD_RES 448 448 Phosphothreonine.
 MOD_RES 452 452 Phosphoserine.
 MOD_RES 461 461 Phosphothreonine.
 MOD_RES 465 465 Phosphoserine.
 MOD_RES 469 469 Phosphoserine.
 MOD_RES 475 475 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 661 AA 
Protein Sequence
MTGGRFDFDD GGTYCGGWEE GKAHGHGICT GPKGQGEYSG SWSHGFEVVG GYTWPSGNTY 60
QGYWAQGKRH GLGVETKGKW MYRGEWSHGF KGRYGVRQSL CTPARYEGTW SNGLQDGYGV 120
ETYGDGGTYQ GQWAGGMRHG YGVRQSVPYG MATVIRSPLR TSLASLRSEQ SNGSVLHDAA 180
AAADSPAGTR GGFVLNFHAD AELAGKKKGG LFRRGSLLGS MKLRKSESKS SISSKRSSVR 240
SDAAMSRISS SDANSTISFG DVDCDFCPVE DHVDATTTET YMGEWKNDKR NGFGVSERSN 300
GMKYEGEWAN NKRHGYGCTV FPDGSKEEGK YKNNILVRGI RKQLIPIRHT KTREKVDRAI 360
EGAQRAAAMA RTKVEIANSR TAHARAKADA ADQAALAARQ ECDIARAVAR ELSPDFYQPG 420
PDYVKQRFQE GVDAKENPEE KVPEKPPTPK ESPHFYRKGT TPPRSPEASP KHSHSPASSP 480
KPLKKQNPSS GARLNQDKRS VADEQVTAIV NKPLMSKAPT KEAGAVVPQS KYSGRHHIPN 540
PSNGELHSQY HGYYVKLNAP QHPPVDVEDG DGSSQSSSAL VHKPSANKWS PSKSVTKPVA 600
KESKAEPKAK KSELAIPKNP ASNDSCPALE KEANSGPNSI MIVLVMLLNI GLAILFVHFL 660
T 661 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030314; C:junctional membrane complex; NAS:UniProtKB.
 GO:0014701; C:junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0008307; F:structural constituent of muscle; IEA:Compara.
 GO:0060402; P:calcium ion transport into cytosol; TAS:BHF-UCL.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; TAS:BHF-UCL. 
Interpro
 IPR017191; Junctophilin.
 IPR003409; MORN. 
Pfam
 PF02493; MORN 
SMART
 SM00698; MORN 
PROSITE
  
PRINTS