UniProt Accession

 FBXW5_HUMAN; Q969U6; B2RDZ6; Q59ET5; Q5SPZ8; Q5SPZ9; Q5SQ00; Q5SQ02; Q5SQ03; Q5SQ04; Q8WY79; Q96GJ6; Q9BSU8; Q9H6A8; Q9HBQ6; Q9NSZ3 

Genbank Protein ID

 AK026081; AK315738; CH471090; BC000850; BC004541; BC009429; BC014297; AL807752; AL807752; AL807752; AL807752; BC014130; AB209726; AL137631; AF217998; AF258569 

Genbank Nucleotide ID

 BAB15354.1; BAG38093.1; EAW88307.1; AAH00850.1; AAH04541.2; AAH09429.1; AAH14297.1; CAI12741.1; CAI12743.1; CAI12744.1; CAI12746.1; AAH14130.1; BAD92963.1; CAB70851.1; AAG17240.1; AAG23772.1 

Protein Name

 F-box/WD repeat-containing protein 5 

Protein Synonyms/Alias

 F-box and WD-40 domain-containing protein 5 

Gene Name

 FBXW5 

Gene Synonyms/Alias

 FBW5; PP3971 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
240	NVVKRLFKIQNLNAS	ubiquitination	[1]
299	GPAPAHAKEGLRHFL	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. 

Sequence Annotation

 DOMAIN 3 49 F-box.
 REPEAT 90 129 WD 1.
 REPEAT 467 506 WD 2.
 REPEAT 508 548 WD 3.
 MOTIF 303 311 D-box.
 MOD_RES 151 151 Phosphoserine; by PLK4.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 566 AA 

Protein Sequence

Gene Ontology

 GO:0080008; C:Cul4-RING ubiquitin ligase complex; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0051298; P:centrosome duplication; IMP:UniProtKB.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB. 

Interpro

 IPR001810; F-box_dom_cyclin-like.
 IPR011041; Quinoprot_gluc/sorb_DH.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00256; FBOX
 SM00320; WD40 

PROSITE

 PS50181; FBOX
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS