UniProt Accession

 IPMK_HUMAN; Q8NFU5 

Genbank Protein ID

 AF432853; BK000580; BC065709 

Genbank Nucleotide ID

 AAM97838.1; DAA01362.1; AAH65709.1 

Protein Name

 Inositol polyphosphate multikinase 

Protein Synonyms/Alias

 Inositol 1,3,4,6-tetrakisphosphate 5-kinase 

Gene Name

 IPMK 

Gene Synonyms/Alias

 IMPK 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
150	MDVKIGQKSYDPFAS	ubiquitination	[1]
160	DPFASSEKIQQQVSK	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). 

Sequence Annotation

 REGION 140 148 Substrate binding (By similarity).
 MOTIF 320 330 Nuclear localization signal.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 7 7 Phosphoserine.  

Keyword

 Acetylation; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000824; F:inositol tetrakisphosphate 3-kinase activity; IEA:Compara.
 GO:0008440; F:inositol-1,4,5-trisphosphate 3-kinase activity; IEA:Compara.
 GO:0000823; F:inositol-1,4,5-trisphosphate 6-kinase activity; IEA:EC.
 GO:0032958; P:inositol phosphate biosynthetic process; IEA:Compara.
 GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
 GO:0001841; P:neural tube formation; IEA:Compara. 

Interpro

 IPR005522; IPK. 

Pfam

 PF03770; IPK 

SMART

  

PROSITE

  

PRINTS