UniProt Accession

 BL1S2_MOUSE; Q9CWG9; A2ATZ7; Q6P062 

Genbank Protein ID

 AK010745; AL928960; BC065806 

Genbank Nucleotide ID

 BAB27155.1; CAM23662.1; AAH65806.1 

Protein Name

 Biogenesis of lysosome-related organelles complex 1 subunit 2 

Protein Synonyms/Alias

 BLOC-1 subunit 2 

Gene Name

 Bloc1s2 

Gene Synonyms/Alias

 Blos2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
77	MNKLTSLKYLEMKDI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation. 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 143 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; ISS:UniProtKB.
 GO:0097345; P:mitochondrial outer membrane permeabilization; ISS:UniProtKB.
 GO:0031175; P:neuron projection development; NAS:UniProtKB. 

Interpro

 IPR019269; BLOC1_su2. 

Pfam

 PF10046; BLOC1_2 

SMART

  

PROSITE

  

PRINTS