CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cask protein 
Protein Synonyms/Alias
  
Gene Name
 Cask 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
41TGQQFAVKIVDVAKFubiquitination[1]
387LYDKINTKSSPQIRNubiquitination[1]
404SDAVQRAKEVLEEISubiquitination[1]
548QTVEQLQKMLREMRGubiquitination[1]
624QGKLENSKNGTAGLIubiquitination[1]
650CIAMEKTKQEQQASCubiquitination[1]
716IKNTLITKHPDRFAYubiquitination[1]
779TKLETIRKIHEQGLIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 880 AA 
Protein Sequence
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60
REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120
YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180
GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240
QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGA VSQVLDSLEE IHALTDCSEK 360
DLDFLHSVFQ DQHLHTLLDL YDKINTKSSP QIRNPPSDAV QRAKEVLEEI SCYPENNDAK 420
ELKRILTQPH FMALLQTHDV VAHEVYSDEA LRVTPPPTSP YLNGDSPESA NGDMDMENVT 480
RVRLVQFQKN TDEPMGITLK MNELNHCIVA RIMHGGMIHR QGTLHVGDEI REINGISVAN 540
QTVEQLQKML REMRGSITFK IVPSYRTQSS SCEIYVRAQF EYDPAKDDLI PCKEAGIRFR 600
VGDIIQIISK DDHNWWQGKL ENSKNGTAGL IPSPELQEWR VACIAMEKTK QEQQASCTWF 660
GKKKKQYKDK YLAKHNADLV TYEEVVKLPA FKRKTLVLLG AHGVGRRHIK NTLITKHPDR 720
FAYPIPHTTR PPKKDEENGK NYYFVSHDQM MQDISNNEYL EYGSHEDAMY GTKLETIRKI 780
HEQGLIAILD VEPQALKVLR TAEFAPFVVF IAAPTITPGL NEDESLQRLQ KESDVLQRTY 840
AHYFDLTIIN NEIDETIRHL EEAVELVCTA PQWVPVSWVY 880 
Gene Ontology
 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005652; C:nuclear lamina; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0042043; F:neurexin family protein binding; IDA:MGI.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0070509; P:calcium ion import; IMP:MGI.
 GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Compara.
 GO:0090288; P:negative regulation of cellular response to growth factor stimulus; IEA:Compara.
 GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Compara.
 GO:0061045; P:negative regulation of wound healing; IEA:Compara.
 GO:0090280; P:positive regulation of calcium ion import; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR011009; Kinase-like_dom.
 IPR004172; L27.
 IPR014775; L27_C.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF02828; L27
 PF00595; PDZ
 PF00069; Pkinase
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00569; L27
 SM00228; PDZ
 SM00220; S_TKc
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS51022; L27
 PS50106; PDZ
 PS50011; PROTEIN_KINASE_DOM
 PS50002; SH3 
PRINTS