UniProt Accession

 PODXL_HUMAN; O00592; A6NHX8; Q52LZ7; Q53ER6 

Genbank Protein ID

 U97519; AK223573; AC008264; CH236950; CH471070; BC093730; BC112035; BP234810 

Genbank Nucleotide ID

 AAB61574.1; BAD97293.1; EAL24080.1; EAW83786.1; AAH93730.1; AAI12036.1 

Protein Name

 Podocalyxin 

Protein Synonyms/Alias

 GCTM-2 antigen; Gp200; Podocalyxin-like protein 1; PC; PCLP-1 

Gene Name

 PODXL 

Gene Synonyms/Alias

 PCLP; PCLP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
493	TSSEMQEKKVVSLNG	ubiquitination	[1]
494	SSEMQEKKVVSLNGE	ubiquitination	[1]
515	VPLDNLTKDDLDEEE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. 

Sequence Annotation

 MOD_RES 529 529 Phosphoserine.
 MOD_RES 537 537 Phosphoserine.
 MOD_RES 556 556 Phosphothreonine.
 CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 144 144 N-linked (GlcNAc...) (Potential).
 CARBOHYD 360 360 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0030175; C:filopodium; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030027; C:lamellipodium; IDA:UniProtKB.
 GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
 GO:0031528; C:microvillus membrane; ISS:UniProtKB.
 GO:0001726; C:ruffle; IDA:UniProtKB.
 GO:0036057; C:slit diaphragm; ISS:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; ISS:UniProtKB.
 GO:0072175; P:epithelial tube formation; ISS:UniProtKB.
 GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.
 GO:0050900; P:leukocyte migration; IEA:Compara.
 GO:0022408; P:negative regulation of cell-cell adhesion; ISS:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
 GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; IDA:UniProtKB.
 GO:0032534; P:regulation of microvillus assembly; ISS:UniProtKB. 

Interpro

 IPR013836; CD34/Podocalyxin.
 IPR017403; Podocalyxin-like_p1. 

Pfam

 PF06365; CD34_antigen 

SMART

  

PROSITE

  

PRINTS