UniProt Accession

 H3BP22_HUMAN; H3BP22 

Genbank Protein ID

 AP000808; AP003732 

Genbank Nucleotide ID

  

Protein Name

 Carnitine O-palmitoyltransferase 1, liver isoform 

Protein Synonyms/Alias

  

Gene Name

 CPT1A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	LSGLHSWKKKFIRFK	ubiquitination	[1]
86	PSLGIIAKINRTLET	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0031307; C:integral to mitochondrial outer membrane; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:Compara.
 GO:0042755; P:eating behavior; IEA:Compara.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0001676; P:long-chain fatty acid metabolic process; IEA:Compara.
 GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0050796; P:regulation of insulin secretion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara. 

Interpro

 IPR000542; Carn_acyl_trans. 

Pfam

  

SMART

  

PROSITE

  

PRINTS