CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal RNA small subunit methyltransferase I 
Protein Synonyms/Alias
 16S rRNA 2'-O-ribose C1402 methyltransferase; rRNA (cytidine-2'-O-)-methyltransferase RsmI 
Gene Name
 rsmI 
Gene Synonyms/Alias
 yraL; b3146; JW3115 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
73HDHNEQQKAETLLAKacetylation[1]
80KAETLLAKLQEGQNIacetylation[1]
157KGRRDALKAIEAEPRacetylation[1]
260LQAELPLKKAAALAAacetylation[1]
279VKKNALYKYALEQQGacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. In vitro, active on the assembled 30S subunit, but not naked 16S rRNA or 70S ribosomes. 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Methyltransferase; Reference proteome; rRNA processing; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 286 AA 
Protein Sequence
MKQHQSADNS QGQLYIVPTP IGNLADITQR ALEVLQAVDL IAAEDTRHTG LLLQHFGINA 60
RLFALHDHNE QQKAETLLAK LQEGQNIALV SDAGTPLIND PGYHLVRTCR EAGIRVVPLP 120
GPCAAITALS AAGLPSDRFC YEGFLPAKSK GRRDALKAIE AEPRTLIFYE STHRLLDSLE 180
DIVAVLGESR YVVLARELTK TWETIHGAPV GELLAWVKED ENRRKGEMVL IVEGHKAQEE 240
DLPADALRTL ALLQAELPLK KAAALAAEIH GVKKNALYKY ALEQQG 286 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0070677; F:rRNA (cytosine-2'-O-)-methyltransferase activity; IMP:EcoCyc.
 GO:0000453; P:enzyme-directed rRNA 2'-O-methylation; IMP:EcoCyc. 
Interpro
 IPR000878; 4pyrrol_Mease.
 IPR014777; 4pyrrole_Mease_sub1.
 IPR014776; 4pyrrole_Mease_sub2.
 IPR008189; rRNA_ssu_MeTfrase_I.
 IPR018063; SAM_MeTrfase_RsmI_CS. 
Pfam
 PF00590; TP_methylase 
SMART
  
PROSITE
 PS01296; RSMI 
PRINTS