Tag | Content |
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CPLM ID | CPLM-016672 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 10 |
Protein Synonyms/Alias | Zizimin-3 |
Gene Name | Dock10 |
Gene Synonyms/Alias | Kiaa0694; Ziz3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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370 | DPDIDTLKLQKRDSF | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. |
Sequence Annotation | DOMAIN 181 290 PH. DOMAIN 672 850 DHR-1. DOMAIN 1690 2150 DHR-2. MOD_RES 376 376 Phosphoserine. MOD_RES 834 834 N6-acetyllysine (By similarity). MOD_RES 1232 1232 Phosphoserine (By similarity). MOD_RES 1292 1292 Phosphoserine. MOD_RES 1295 1295 Phosphoserine. MOD_RES 1318 1318 Phosphoserine (By similarity). MOD_RES 1440 1440 Phosphothreonine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2150 AA |
Protein Sequence | MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLDP LDYETVIEEL 60 EKTYRDDPLQ DLLFFPSDDF STATVSWDIR TLYSTVPEEA EHRAESLLVK EACKFYSSQW 120 YVVNYKYEQY SGDIRQLPRA EHKPEKLPSH SFEVDHEDAD KDEDTTSHSS SKGGGGAGGT 180 GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF 240 LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR 300 KSAELAELGL DPLDNCVTCE CTLEETDSSE NSLHPDFAKY LTETEDTVKT TRNMGRLNLF 360 SLDPDIDTLK LQKRDSFENE LMIKPFEEKA AKRIMIICRA LNFNLQGCVT ENEYDPVTNI 420 EPFFVSVALY DLRDNRKISA DFHVDLNHPA VRQMLSGTPP ALENGNIDTG TPRQSEEPHI 480 KGLPEEWLKF PKQAVFSVSD PHSEIVLVAK VEKVLMGNIG SGAEPYIKNP DSNKFAQKIL 540 KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LYRQESSKMS SEDLLKLVSD 600 YRRADRISKM QSIPGSLDIA VDNIPLEHPN CVTSSFIPVK PFNVSAQSEP TVEVEEFIYD 660 STKYCRPYRV YKNQIYVYPK HLKYDSQKCF NKARNITVCI EFKNSDDDGA KPMKCIYGKP 720 GGPLFTSSAY TAVLHHSQNP DFSDEVKIEL PTQLHGKHHL LFSFYHITCD INAKANAKKK 780 EALETSVGYA WLPLMKHDQI ASQEYNIPIA TTLPPNYLSI QDPTSAKHGG SDIKWVDGGK 840 PLFKVSTFVV STVNTQDPHV NAFFRQCQKR EKDMSQSPTS SFVRACKNLL NVDKIHSIMS 900 FLPIILNQLF KILVQNEEDE ITATVTRVLA DIVAKCHEEQ LDHSVQSYIK FVFKTKSYKE 960 RTIHEELAKN LSDLLKSNDS TIVKHVLEHS WFFFAIILKS MAQHLIDTNK IQLPRAQRFP 1020 ESYQSELDNL VMGLCDHVIW KCKEAPEETK RANHSVARFL KRCFTFMDRG FVFKMVNNYI 1080 SMFSSGEFKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSESI RELHASDMPE 1140 YSVTNEFCRK HFLIGILLRE VGFALQEDQD IRHLALAVLK NLMAKHSFDD RYREPRKQAQ 1200 IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQTQT SMKHATSVDT 1260 SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTT EKSSEKTDNC EKIPRPLSLI 1320 GSTLRFDKLD QAETRSLLMC FLHIMKTISD ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR 1380 YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHTTSGH EGHKQHRSQT 1440 LPIIRGKNAL SNPKLLQMLD NSMNSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQV 1500 HQRQLQQSDC QNSLMKRVFD TYMLFFQVNQ SASALKHVFA SLRLFVCKFP SAFFQGPADL 1560 CGSFCYEVLK CCNHRSRLTQ MEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD 1620 AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM 1680 LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW 1740 KMEKICTPPL LPEDTQPCDS NLLLTTPGGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ 1800 DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY 1860 LKVAEVVNSE KRLFGRYYRV AFYGQAVGFF EEEEGKEYIY KEPKLTGLSE ISQRLLKLYA 1920 DKFGADNVKI IQDSNKVNPK DLDPKYAYIQ VTYVTPFFEE KEIEDRKTDF EMHHNINRFV 1980 FETPFTLSGK KHGGVAEQCK RRTVLTTSHL FPYVKKRIQV ISQSSTELNP IEVAIDEMSR 2040 KVSELNQLCT TEEVDMIRLQ LKLQGSVSVK VNAGPMAYAR AFLEETNAKK YPDNQVKLLK 2100 EIFRQFADAC GQALDVNERL IKEDQLEYQE ELRSHYKDML SELSAIMNEQ 2150 |
Gene Ontology | GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |