CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029178
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein phosphatase 2A activator 
Protein Synonyms/Alias
  
Gene Name
 PPP2R4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
27TQNFIIPKKEIHTVPubiquitination[1]
69NEGVKGKKLTFEYRVubiquitination[2]
109QPSRFGNKAYRTWYAubiquitination[2]
248PRHFVDEKAVNENHKubiquitination[1]
292SAVPSWSKVNQGLIRubiquitination[2, 3]
302QGLIRMYKAECLEKFacetylation[4]
302QGLIRMYKAECLEKFubiquitination[2]
308YKAECLEKFPVIQHFacetylation[4]
308YKAECLEKFPVIQHFubiquitination[2]
316FPVIQHFKFGSLLPIubiquitination[2, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 329 AA 
Protein Sequence
MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQVPFGTVA YADYIGFILT 60
LNEGVKGKKL TFEYRVSEAI EKLVALLNTL DRWIDETPPV DQPSRFGNKA YRTWYAKLDE 120
EAENLVATVV PTHLAAAVPE VAVYLKESVG NSTRIDYGTG HEAAFAAFLC CLCKIGVLRV 180
DDQIAIVFKV FNRYLEVMRK LQKTYRMEPA GSQGVWGLDD FQFLPFIWGS SQLIDHPYLE 240
PRHFVDEKAV NENHKDYMFL ECILFITEMK TGPFAEHSNQ LWNISAVPSW SKVNQGLIRM 300
YKAECLEKFP VIQHFKFGSL LPIHPVTSG 329 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0019211; F:phosphatase activator activity; IEA:InterPro. 
Interpro
 IPR004327; Phstyr_phstse_ac. 
Pfam
 PF03095; PTPA 
SMART
  
PROSITE
  
PRINTS