CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012187
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Angio-associated migratory cell protein 
Protein Synonyms/Alias
  
Gene Name
 AAMP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115VTGGEDDKAFVWRLSubiquitination[1]
245TIRIWDLKQGSPIHVubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. 
Sequence Annotation
 REPEAT 89 129 WD 1.
 REPEAT 132 171 WD 2.
 REPEAT 173 212 WD 3.
 REPEAT 214 254 WD 4.
 REPEAT 258 299 WD 5.
 REPEAT 315 354 WD 6.
 REPEAT 356 395 WD 7.
 REPEAT 398 433 WD 8.  
Keyword
 Angiogenesis; Cell membrane; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Membrane; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 434 AA 
Protein Sequence
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 60
NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 120
LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 180
EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 240
IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 300
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 360
IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 420
DHKAKVFCVQ RPDR 434 
Gene Ontology
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008201; F:heparin binding; TAS:ProtInc.
 GO:0001525; P:angiogenesis; NAS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
 GO:0014909; P:smooth muscle cell migration; IEP:UniProtKB. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS