UniProt Accession

 TNR9_HUMAN; Q07011 

Genbank Protein ID

 U03397; L12964; AY438976; AL009183; BC006196 

Genbank Nucleotide ID

 AAA53133.1; AAA62478.2; AAR05440.1; CAB57398.1; AAH06196.1 

Protein Name

 Tumor necrosis factor receptor superfamily member 9 

Protein Synonyms/Alias

 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD137 

Gene Name

 TNFRSF9 

Gene Synonyms/Alias

 CD137; ILA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
219	VVKRGRKKLLYIFKQ	ubiquitination	[1, 2, 3]
225	KKLLYIFKQPFMRPV	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. 

Sequence Annotation

 REPEAT 24 45 TNFR-Cys 1.
 REPEAT 47 86 TNFR-Cys 2.
 REPEAT 87 118 TNFR-Cys 3.
 REPEAT 119 159 TNFR-Cys 4.
 REGION 214 255 Interaction with LRR-1.
 CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
 CARBOHYD 149 149 N-linked (GlcNAc...) (Potential).
 DISULFID 28 37 By similarity.
 DISULFID 31 45 By similarity.
 DISULFID 48 62 By similarity.
 DISULFID 65 78 By similarity.
 DISULFID 68 86 By similarity.
 DISULFID 88 94 By similarity.
 DISULFID 99 106 By similarity.
 DISULFID 102 117 By similarity.
 DISULFID 121 133 By similarity.
 DISULFID 139 158 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 255 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc. 

Interpro

 IPR001368; TNFR/NGFR_Cys_rich_reg.
 IPR020413; TNFR_9. 

Pfam

 PF00020; TNFR_c6 

SMART

 SM00208; TNFR 

PROSITE

 PS00652; TNFR_NGFR_1
 PS50050; TNFR_NGFR_2 

PRINTS

 PR01924; TNFACTORR9.