| Tag | Content |
|---|
| CPLM ID | CPLM-016089 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nebulin-related-anchoring protein |
Protein Synonyms/Alias | N-RAP |
Gene Name | Nrap |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 77 | TPLNLTLKKSVAAMG | ubiquitination | [1] | | 89 | AMGGIDGKEDGEPFK | ubiquitination | [1] | | 165 | DREQQQGKGSFPAMI | ubiquitination | [1] | | 180 | TPAYQRAKAANQLAS | ubiquitination | [1] | | 192 | LASQVQYKRGHDERV | ubiquitination | [1] | | 215 | TPELLRAKAGGQLQN | ubiquitination | [1] | | 1223 | TPNLLHAKYSNQITN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. |
Sequence Annotation | DOMAIN 4 64 LIM zinc-binding.
REPEAT 173 200 Nebulin 1.
REPEAT 201 235 Nebulin 2.
REPEAT 244 271 Nebulin 3.
REPEAT 313 340 Nebulin 4.
REPEAT 345 379 Nebulin 5.
REPEAT 386 414 Nebulin 6.
REPEAT 416 450 Nebulin 7.
REPEAT 484 518 Nebulin 8.
REPEAT 519 553 Nebulin 9.
REPEAT 555 589 Nebulin 10.
REPEAT 599 623 Nebulin 11.
REPEAT 624 658 Nebulin 12.
REPEAT 659 689 Nebulin 13.
REPEAT 699 721 Nebulin 14.
REPEAT 723 757 Nebulin 15.
REPEAT 758 792 Nebulin 16.
REPEAT 794 828 Nebulin 17.
REPEAT 841 866 Nebulin 18.
REPEAT 867 893 Nebulin 19.
REPEAT 898 932 Nebulin 20.
REPEAT 943 960 Nebulin 21.
REPEAT 966 1000 Nebulin 22.
REPEAT 1001 1035 Nebulin 23.
REPEAT 1037 1071 Nebulin 24.
REPEAT 1075 1109 Nebulin 25.
REPEAT 1110 1136 Nebulin 26.
REPEAT 1141 1175 Nebulin 27.
REPEAT 1180 1203 Nebulin 28.
REPEAT 1209 1243 Nebulin 29.
REPEAT 1244 1278 Nebulin 30.
REPEAT 1280 1314 Nebulin 31.
REPEAT 1318 1352 Nebulin 32.
REPEAT 1353 1379 Nebulin 33.
REPEAT 1384 1418 Nebulin 34.
REPEAT 1425 1446 Nebulin 35.
REPEAT 1452 1478 Nebulin 36.
REPEAT 1487 1521 Nebulin 37.
REPEAT 1523 1557 Nebulin 38.
REPEAT 1561 1595 Nebulin 39.
REPEAT 1596 1630 Nebulin 40.
REPEAT 1637 1661 Nebulin 41. |
Keyword | Actin-binding; Alternative splicing; Complete proteome; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1728 AA |
Protein Sequence | MNVQACSRCG YGVYPAEKIS CIDQTWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK 60
NNTFTSVYHT PLNLTLKKSV AAMGGIDGKE DGEPFKSVLH WDMKSKAGAG AASRLMNERD 120
YWPGYAEGNT WCPGALPDPE IVRMVEARQS LGEGYTEDRE QQQGKGSFPA MITPAYQRAK 180
AANQLASQVQ YKRGHDERVS TFTPVADTPE LLRAKAGGQL QNDVRYTEDG GQQRGKGSFP 240
AMITPAYQIA KRATELASDV RYHQQYHREM KGMASPVGAE GGMTKDSVDR CGQVYSEECD 300
EPRGKGSFPA MITPAYQNAK KANELVSDIK YRQDFHKMKG AAHFHSLAAQ DNLVLKRAQS 360
VSKLVSEVEY KKGLENSKGH SINYCETPQF RNVSKISKFT SDNKYKENYQ TQLRGHYDGV 420
GMDRRMLHAL KVGSLASNVA YKADYKHDVV DYNYLATATP FYQTTMRLVP LKDVNYRQNI 480
DRMKFSSVTN TPQIVQAKIN AQQLSHVNYR ADYERNKLNY TLPQDAPQLL KAKANAELFS 540
EVKYKEGWQK TKGKGFEMKL DAMSLLAAKA SGELASSVKY KEEYEKMKGR ALGATDSKLL 600
HSLQVAKMSS EVEYKKGFEE SKTHFNLPMD MVNLRHAKKA QALASDLDYR KKLHDYTVLP 660
EDMKTQWAKK AYGLQSELQY KADLAWMRGV GWLTEGSLNL EQAKKAGQLI SEKNYRQRVD 720
ELKFTSVADS SQMEHAKKSQ GLQNAVAYKA GNEQSVHQYT ISKDEPLFLR ARANAAQLSE 780
TLYKSSWEKQ KAKGFELRLD SLAFLTAKAK RDLASEVKYK EDYERSRGKL IGAKSAQGDS 840
QMSHSLQMSK LQSDLEYKKG FEDTRSQCHI SLDMVHLVHA RQAQHLATDV GYRTASHCFT 900
ALPTDMKVEW AKKAYGLQSD NQYRADMKWM KGTGWVATGS LHVEQAKKAG ELISEKKYRQ 960
HPDALKFTSI KDTPEMVQAR ISYTQAVDRL YREQGENVKH HYTQTADLPE VLLAKLNAMN 1020
ISETRYKESW SRLRDGGYKL RLDALPFQAA KASSEVISDY KYKEAFERMK GQMLGSRSLE 1080
DDLSLAHSVH ATSLQSDVNY KKGFEHAKAH FHLPLDMVTL VHAKKAQTLA SDQDYRHPLP 1140
QHTVLAEDLR LSCAKKAHKL QSENLYRSDL NFMRGVPCVV PGTLEIEGRK KASELISESK 1200
YRQHPGSFKY TAVTDTPNLL HAKYSNQITN ERLYKAAGED ARHQYTMTLG LPEFIRAKTN 1260
AANLSEAKYK EAWHNLRAQG YKLTIDALPF QAARASGDIA SDFLYRHEFV KERGQLIGVR 1320
NVSDDPRLLH CLRMGQLQSE NQYRKEAASS QAQCHLPMDM MYLVHARKAQ ALASDHDYRT 1380
QCHEFTALPE DLKMAWAKKA HALQSEFRYK ADLMGMKGTG WLALQSPQIE SAKKAGDLIS 1440
ETKYRKKPDS IKFTTVVDSP DLIHAKESYM HCNERLYRLG DAASLHRYTP IPDHPDFTRA 1500
RMNAMHLSDK VYRNAWEQSR AGGYDFRLDA IPFQTARVSR DIASDFRYKE AFLRDRGLQI 1560
GYRSISDDPR TTHFLRVGRL QSDNEYRKAF AKGRSQFHSR ADQPGFLQAK RSQQLASDVL 1620
YRQPLPQHTS DPEQLGLKHA RKAHQLQSDV KYKSDLNLTR GVGWTPPGSY KVEMARRAAE 1680
LANRRGPGIR GASVEPEAAA ALGDHQSRGV NPDASEILHI HKKKTLLM 1728 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |