UniProt Accession

 CAH3_HUMAN; P07451; B2R867; B3KUC8; O60842 

Genbank Protein ID

 M29458; M29452; AK096880; AK313254; CH471068; BC004897; AJ006473 

Genbank Nucleotide ID

 AAA52293.1; BAG53390.1; BAG36064.1; EAW87133.1; AAH04897.1; CAA07056.1 

Protein Name

 Carbonic anhydrase 3 

Protein Synonyms/Alias

 Carbonate dehydratase III; Carbonic anhydrase III; CA-III 

Gene Name

 CA3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	HLVHWNPKYNTFKEA	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Reversible hydration of carbon dioxide. 

Sequence Annotation

 REGION 64 67 Involved in proton transfer.
 REGION 198 199 Substrate binding (By similarity).
 ACT_SITE 127 127 By similarity.
 METAL 94 94 Zinc; catalytic.
 METAL 96 96 Zinc; catalytic.
 METAL 119 119 Zinc; catalytic.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 182 182 S-glutathionyl cysteine (By similarity).
 MOD_RES 187 187 S-glutathionyl cysteine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Glutathionylation; Lyase; Metal-binding; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004089; F:carbonate dehydratase activity; TAS:ProtInc.
 GO:0016151; F:nickel cation binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0015701; P:bicarbonate transport; TAS:Reactome.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018441; Carbonic_anhydrase_CA3. 

Pfam

 PF00194; Carb_anhydrase 

SMART

 SM01057; Carb_anhydrase 

PROSITE

 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 

PRINTS