CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026977
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein EZH2 
Protein Synonyms/Alias
  
Gene Name
 EZH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
492CKAQCNTKQCPCYLAubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 669 AA 
Protein Sequence
CSVTSDLDFP TQVIPLKTLN AVASVPIMYS WSPLQQNFMV EDETVLHNIP YMGDEVLDQD 60
GTFIEELIKN YDGKVHGDRE CGFINDEIFV ELVNALGQYN DDDDDDDGDD PEEREEKQKD 120
LEDHRDDKES RPPRKFPSDK IFEAISSMFP DKGTAEELKE KYKELTEQQL PGALPPECTP 180
NIDGPNAKSV QREQSLHSFH TLFCRRCFKY DCFLHRKCNY SFHATPNTYK RKNTETALDN 240
KPCGPQCYQH LEGAKEFAAA LTAERIKTPP KRPGGRRRGR LPNNSSRPST PTINVLESKD 300
TDSDREAGTE TGGENNDKEE EEKKDETSSS SEANSRCQTP IKMKPNIEPP ENVEWSGAEA 360
SMFRVLIGTY YDNFCAIARL IGTKTCRQVY EFRVKESSII APAPAEDVDT PPRKKKRKHR 420
LWAAHCRKIQ LKKDGSSNHV YNYQPCDHPR QPCDSSCPCV IAQNFCEKFC QCSSECQNRF 480
PGCRCKAQCN TKQCPCYLAV RECDPDLCLT CGAADHWDSK NVSCKNCSIQ RGSKKHLLLA 540
PSDVAGWGIF IKDPVQKNEF ISEYCGEIIS QDEADRRGKV YDKYMCSFLF NLNNDFVVDA 600
TRKGNKIRFA NHSVNPNCYA KVMMVNGDHR IGIFAKRAIQ TGEELFFDYR YSQADALKYV 660
GIEREMEIP 669 
Gene Ontology
 GO:0035098; C:ESC/E(Z) complex; IEA:Compara.
 GO:0045120; C:pronucleus; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0001047; F:core promoter binding; IEA:Compara.
 GO:0042054; F:histone methyltransferase activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0021695; P:cerebellar cortex development; IEA:Compara.
 GO:0070314; P:G1 to G0 transition; IEA:Compara.
 GO:0070734; P:histone H3-K27 methylation; IEA:Compara.
 GO:0045605; P:negative regulation of epidermal cell differentiation; IEA:Compara.
 GO:0051154; P:negative regulation of striated muscle cell differentiation; IEA:Compara.
 GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0014013; P:regulation of gliogenesis; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IEA:Compara. 
Interpro
 IPR026489; CXC_dom.
 IPR001005; SANT/Myb.
 IPR001214; SET_dom. 
Pfam
 PF00856; SET 
SMART
 SM00717; SANT
 SM00317; SET 
PROSITE
 PS51633; CXC
 PS50280; SET 
PRINTS