CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019162
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynein heavy chain 11, axonemal 
Protein Synonyms/Alias
 Axonemal beta dynein heavy chain 11; Ciliary dynein heavy chain 11 
Gene Name
 DNAH11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
449ASYFMGRKLRPWDFQubiquitination[1]
3914VEEKLGAKYVERTRLubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. 
Sequence Annotation
 NP_BIND 1900 1907 ATP (Potential).
 NP_BIND 2181 2188 ATP (Potential).
 NP_BIND 2517 2524 ATP (Potential).
 NP_BIND 2862 2869 ATP (Potential).
 REGION 1 1861 Stem (By similarity).
 REGION 1862 2083 AAA 1 (By similarity).
 REGION 2143 2373 AAA 2 (By similarity).
 REGION 2479 2726 AAA 3 (By similarity).
 REGION 2824 3073 AAA 4 (By similarity).
 REGION 3079 3410 Stalk (By similarity).
 REGION 3466 3693 AAA 5 (By similarity).
 REGION 3903 4129 AAA 6 (By similarity).  
Keyword
 ATP-binding; Cell projection; Ciliopathy; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Dynein; Kartagener syndrome; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Primary ciliary dyskinesia; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4523 AA 
Protein Sequence
MAAQVAAREA RDFREAPTLR LTSGAGLEAV GAVELEEEEE NEEEAAARRA RSFAQDARVR 60
FLGGRLAMML GFTEEKWSQY LESEDNRQVL GEFLESTSPA CLVFSFAASG RLAASQEIPR 120
DANHKLVFIS KKITESIGVN DFSQVVLFGE LPALSLGHVS AFLDEILVPV LSNKNNHKSW 180
SCFTSQDMEY HIEVMKKKMY IFRGKMSRRT LLPIPTVAGK MDLDQNCSEN KPPSNERIIL 240
HAIESVVIEW SHQIQEIIER DSVQRLLNGL HLSPQAELDF WMMRRENLSC IYDQLQAPVV 300
LKMVKILTTK QSSYFPTLKD IFLAVENALL EAQDVELYLR PLRRHIQCLQ ETEFPQTRIL 360
IAPLFHTICL IWSHSKFYNT PARVIVLLQE FCNLFINQAT AYLSPEDLLR GEIEESLEKV 420
QVAVNILKTF KNSFFNYRKK LASYFMGRKL RPWDFQSHLV FCRFDKFLDR LIKIEDIFAT 480
TLEFEKLERL EFGGTKGAIL NGQVHEMSEE LMELCKLFKQ STYDPSDCTN MEFESDYVAF 540
KSKTLEFDRR LGTIICEAFF NCNGLEAAFK LLTIFGNFLE KPVVMEIFSL HYSTLVHMFN 600
TELDVCKQLY NEHMKQIECG HVVLNKNMPF TSGNMKWAQQ VLQRLQMFWS NFASLRYLFL 660
GNPDHALVYQ KYVEMTTLLD QFESRIYNEW KSNVDEICEF NLNQPLVKFS AINGLLCVNF 720
DPKLVAVLRE VKYLLMLKKQ DIPDSALAIF KKRNTILKYI GNLDLLVQGY NKLKQTLLEV 780
EYPLIEDELR AIDEQLTAAT TWLTWQDDCW GYIERVRAAT SELEHRVERT QKNVKVIQQT 840
MRGWARCVLP PRREHRREAA FTLEDKGDLF TKKYKLIQGD GCKIHNLVEE NRKLFKANPS 900
LDTWKIYVEF IDDIVVEGFF QAIMHDLDFF LKNTEKQLKP APFFQAQMIL LPPEIVFKPS 960
LDREAGDGFY DLVEEMLCNS FRMSAQMNRI ATHLEIKNYQ NDMDNMLGLA EVRQEIMNRV 1020
VNVINKVLDF RNTLETHTYL WVDDRAEFMK HFLLYGHAVS SDEMDAHANE EIPEQPPTLE 1080
QFKEQIDIYE ALYVQMSKFE DFRVFDSWFK VDMKPFKVSL LTIIKKWSWM FQEHLLRFVI 1140
DSLNELQEFI KETDSGLQRE LNEGDHDGLV DIMVHLLAVR SRQRATDELF EPLKETITLL 1200
ESYGQKMPEQ VYIQLEELPE RWETTKKIAA TVRHEVSPLH NAEVTLIRKK CILFDAKQAE 1260
FRERFRHYAP LGFNAENPYT ALDKANEELE ALEEEMLQMQ ESTRLFEVAL PEYKQMKQCR 1320
KEIKLLKGLW DVIIYVRRSI DNWTKTQWRQ IHVEQMDVEL RRFAKASSIT EIWSLNKEVR 1380
VWDAYTGLEG TVKDMTASLR AITELQSPAL RDRHWHQLMK AIGVKFLINE ATTLADLLAL 1440
RLHRVEDDVR RIVDKAVKEL GTEKVITEIS QTWATMKFSY EVHYRTGIPL LKSDEQLFET 1500
LEHNQVQLQT LLQSKYVEYF IEQVLSWQNK LNIADLVIFT WMEVQRTWSH LESIFVCSED 1560
IRIQLVKDAR RFDGVDAEFK ELMFKTAKVE NVLEATCRPN LYEKLKDLQS RLSLCEKALA 1620
EYLETKRIAF PRFYFVSSAD LLDILSKGAQ PKQVTCHLAK LFDSIADLQF EDNQDVSAHR 1680
AVGMYSKEKE YVPFQAECEC VGHVETWLLQ LEQTMQETVR HSITEAIVAY EEKPRELWIF 1740
DFPAQVALTS SQIWWTTDVG IAFSRLEEGY ETALKDFHKK QISQLNTLIT LLLGELPPGD 1800
RQKIMTICTI DVHARDVVAK LISQKQVVVS PQAFTWLSQL RHRWEDTQKH CFVNICDAQF 1860
QYFYEYLGNS PRLVITPLTD RCYITLTQSL HLTMSGAPAG PAGTGKTETT KDLGRALGMM 1920
VYVFNCSEQM DYKSIGNIYK GLVQTGAWGC FDEFNRISVE VLSVVAVQVK MIHDAIRNRK 1980
KRFVFLGEAI TLKPSVGIFI TMNPGYAGRT ELPENLKALF RPCAMVAPDI ELICEILLVA 2040
EGFVDARALA RKFITLYTLC KELLSKQDHY DWGLRAIKSV LVVAGSLKRG DKNRPEDQVL 2100
MRALRDFNMP KIVTDDIPVF LGLVGDLFPA LDVPRRRKLH FEQMVRQSTL ELRLQPEESF 2160
ILKVVQLEEL LAVRHSVFVV GNAGTGKSKI LRTLNRTYVN MKQKPVWNDL NPKAVTTDEL 2220
FGFIHHATRE WKDGKIVYSY FIGLFSSILR EQANLKHDGP KWIVLDGDID PMWIESLNTV 2280
MDDNKVLTLA SNERIALTPF MRLLFEIHHL RSATPATVSR AGILYVNPQD LGWNPYVASW 2340
IDRRRHQSEK ANLTILFDKY VPACLDKLRT SFKTITSIPE SSLVQTLCVL LECLLTPENV 2400
PSDSPKEVYE VYFVFACIWA FGGTLLQDQI SDYQADFSRW WQKEMKAVKF PSQGTIFDYY 2460
VDHKTKKLLP WADKIAQFTM DPDVPLQTVL VHTTETARLR YFMELLLEKG KPLMLVGNAG 2520
VGKTVFVGDT LASLSEDYIV SRVPFNYYTT STALQKILEK PLEKKAGHNY GPGGNKKLIY 2580
FIDDMNMPEV DLYGTVQPHT LIRQHIDYGH WYDRQKVMLK EIHNCQYVAC MNPMVGSFTI 2640
SPRLQRHFTV FAFNFPSLDA LNTIYGQIFS FHFQQQAFAP SILRSGPTLI QATIAFHQTM 2700
MCNFLPTAIK FHYIFNLRDL SNVFQGILFA SPECLKGPLD LIHLWLHESA RVYGDKLIDK 2760
KDCDLFQRRM LETAYKYFEG IDSHMLLQQP LIYCHFADRG KDPHYMPVKD WEVLKTILTE 2820
TLDNYNELNA AMHLVLFEDA MQHVCRISRI LRTPQGCALL VGVGGSGKQS LSRLAAYLRG 2880
LEVFQITLTE GYGIQELRVD LANLYIRTGA KNMPTVFLLT DAQVLDESFL VLINDLLASG 2940
EIPDLFSDED VDKIISGIHN EVHALGMVDS RENCWKFFMA RVRLQLKIIL CFSPVGRTLR 3000
VRARKFPAIV NCTAIDWFHA WPQEALVSVS RRFIEETKGI EPVHKDSISL FMAHVHTTVN 3060
EMSTRYYQNE RRHNYTTPKS FLEQISLFKN LLKKKQNEVS EKKERLVNGI QKLKTTASQV 3120
GDLKARLASQ EAELQLRNHD AEALITKIGL QTEKVSREKT IADAEERKVT AIQTEVFQKQ 3180
RECEADLLKA EPALVAATAA LNTLNRVNLS ELKAFPNPPI AVTNVTAAVM VLLAPRGRVP 3240
KDRSWKAAKV FMGKVDDFLQ ALINYDKEHI PENCLKVVNE HYLKDPEFNP NLIRTKSFAA 3300
AGLCAWVINI IKFYEVYCDV EPKRQALAQA NLELAAATEK LEAIRKKLVD LDRNLSRLTA 3360
SFEKATAEKV RCQEEVNQTN KTIKLANRLV KELEAKKIRW GQSIKSFEAQ EKTLCGDVLL 3420
TAAFVSYVGP FTRQYRQELV HCKWVPFLQQ KVSIPLTEGL DLISMLTDDA TIAAWNNEGL 3480
PSDRMSTENA AILTHCERWP LVIDPQQQGI KWIKNKYGMD LKVTHLGQKG FLNAIETALA 3540
FGDVILIENL EETIDPVLDP LLGRNTIKKG KYIRIGDKEC EFNKNFRLIL HTKLANPHYK 3600
PELQAQTTLL NFTVTEDGLE AQLLAEVVSI ERPDLEKLKL VLTKHQNDFK IELKYLEDDL 3660
LLRLSAAEGS FLDDTKLVER LEATKTTVAE IEHKVIEAKE NERKINEARE CYRPLAARAS 3720
LLYFVINDLQ KINPLYQFSL KAFNVLFHRA IEQADKVEDM QGRISILMES ITHAVFLYTS 3780
QALFEKDKLT FLSQMAFQIL LRKKEIDPLE LDFLLRFTVE HTHLSPVDFL TSQSWSAIKA 3840
IAVMEEFRGI DRDVEGSAKQ WRKWVESECP EKEKLPQEWK KKSLIQKLIL LRAMRPDRMT 3900
YALRNFVEEK LGAKYVERTR LDLVKAFEES SPATPIFFIL SPGVDALKDL EILGKRLGFT 3960
IDSGKFHNVS LGQGQETVAE VALEKASKGG HWVILQNVHL VAKWLGTLEK LLERFSQGSH 4020
RDYRVFMSAE SAPTPDEHII PQGLLENSIK ITNEPPTGML ANLHAALYNF DQDTLEICSK 4080
EQEFKSILFS LCYFHACVAG RLRFGPQGWS RSYPFNPGDL TICASVLYNY LEANSKVPWE 4140
DLRYLFGEIM YGGHITDDWD RKLCRVYLEE FMNPSLTEDE LMLAPGFAAP PYLDYAGYHQ 4200
YIEEMLPPES PALYGLHPNA EIEFLTVTSN TLFRTLLEMQ PRNALSGDEL GQSTEEKVKN 4260
VLDDILEKLP EEFNMAEIMQ KNSNRSPYVL VCFQECERMN ILIREIRISL EQLDLSLKGE 4320
LALSPAVEAQ QFALSYDTVP DTWSKLAYPS TYGLAQWFND LLLRCRELDT WTQDLTLPAV 4380
VWLSGFFNPQ SFLTAIMQTM ARKNEWPLDK TRLTADVTKK TKEDYGHPPR EGAYLHGLFM 4440
EGARWDTQAG TIVEARLKEL ACPMPVIFAK ATPVDRQETK QTYECPVYRT KLRGPSYIWT 4500
FRLKSEEKTA KWVLAGVALL LEA 4523 
Gene Ontology
 GO:0005858; C:axonemal dynein complex; NAS:UniProtKB.
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; NAS:UniProtKB.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0001539; P:ciliary or flagellar motility; IEA:Compara.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS