Tag | Content |
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CPLM ID | CPLM-019162 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dynein heavy chain 11, axonemal |
Protein Synonyms/Alias | Axonemal beta dynein heavy chain 11; Ciliary dynein heavy chain 11 |
Gene Name | DNAH11 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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449 | ASYFMGRKLRPWDFQ | ubiquitination | [1] | 3914 | VEEKLGAKYVERTRL | ubiquitination | [1] |
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Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. |
Sequence Annotation | NP_BIND 1900 1907 ATP (Potential). NP_BIND 2181 2188 ATP (Potential). NP_BIND 2517 2524 ATP (Potential). NP_BIND 2862 2869 ATP (Potential). REGION 1 1861 Stem (By similarity). REGION 1862 2083 AAA 1 (By similarity). REGION 2143 2373 AAA 2 (By similarity). REGION 2479 2726 AAA 3 (By similarity). REGION 2824 3073 AAA 4 (By similarity). REGION 3079 3410 Stalk (By similarity). REGION 3466 3693 AAA 5 (By similarity). REGION 3903 4129 AAA 6 (By similarity). |
Keyword | ATP-binding; Cell projection; Ciliopathy; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Dynein; Kartagener syndrome; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Primary ciliary dyskinesia; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4523 AA |
Protein Sequence | MAAQVAAREA RDFREAPTLR LTSGAGLEAV GAVELEEEEE NEEEAAARRA RSFAQDARVR 60 FLGGRLAMML GFTEEKWSQY LESEDNRQVL GEFLESTSPA CLVFSFAASG RLAASQEIPR 120 DANHKLVFIS KKITESIGVN DFSQVVLFGE LPALSLGHVS AFLDEILVPV LSNKNNHKSW 180 SCFTSQDMEY HIEVMKKKMY IFRGKMSRRT LLPIPTVAGK MDLDQNCSEN KPPSNERIIL 240 HAIESVVIEW SHQIQEIIER DSVQRLLNGL HLSPQAELDF WMMRRENLSC IYDQLQAPVV 300 LKMVKILTTK QSSYFPTLKD IFLAVENALL EAQDVELYLR PLRRHIQCLQ ETEFPQTRIL 360 IAPLFHTICL IWSHSKFYNT PARVIVLLQE FCNLFINQAT AYLSPEDLLR GEIEESLEKV 420 QVAVNILKTF KNSFFNYRKK LASYFMGRKL RPWDFQSHLV FCRFDKFLDR LIKIEDIFAT 480 TLEFEKLERL EFGGTKGAIL NGQVHEMSEE LMELCKLFKQ STYDPSDCTN MEFESDYVAF 540 KSKTLEFDRR LGTIICEAFF NCNGLEAAFK LLTIFGNFLE KPVVMEIFSL HYSTLVHMFN 600 TELDVCKQLY NEHMKQIECG HVVLNKNMPF TSGNMKWAQQ VLQRLQMFWS NFASLRYLFL 660 GNPDHALVYQ KYVEMTTLLD QFESRIYNEW KSNVDEICEF NLNQPLVKFS AINGLLCVNF 720 DPKLVAVLRE VKYLLMLKKQ DIPDSALAIF KKRNTILKYI GNLDLLVQGY NKLKQTLLEV 780 EYPLIEDELR AIDEQLTAAT TWLTWQDDCW GYIERVRAAT SELEHRVERT QKNVKVIQQT 840 MRGWARCVLP PRREHRREAA FTLEDKGDLF TKKYKLIQGD GCKIHNLVEE NRKLFKANPS 900 LDTWKIYVEF IDDIVVEGFF QAIMHDLDFF LKNTEKQLKP APFFQAQMIL LPPEIVFKPS 960 LDREAGDGFY DLVEEMLCNS FRMSAQMNRI ATHLEIKNYQ NDMDNMLGLA EVRQEIMNRV 1020 VNVINKVLDF RNTLETHTYL WVDDRAEFMK HFLLYGHAVS SDEMDAHANE EIPEQPPTLE 1080 QFKEQIDIYE ALYVQMSKFE DFRVFDSWFK VDMKPFKVSL LTIIKKWSWM FQEHLLRFVI 1140 DSLNELQEFI KETDSGLQRE LNEGDHDGLV DIMVHLLAVR SRQRATDELF EPLKETITLL 1200 ESYGQKMPEQ VYIQLEELPE RWETTKKIAA TVRHEVSPLH NAEVTLIRKK CILFDAKQAE 1260 FRERFRHYAP LGFNAENPYT ALDKANEELE ALEEEMLQMQ ESTRLFEVAL PEYKQMKQCR 1320 KEIKLLKGLW DVIIYVRRSI DNWTKTQWRQ IHVEQMDVEL RRFAKASSIT EIWSLNKEVR 1380 VWDAYTGLEG TVKDMTASLR AITELQSPAL RDRHWHQLMK AIGVKFLINE ATTLADLLAL 1440 RLHRVEDDVR RIVDKAVKEL GTEKVITEIS QTWATMKFSY EVHYRTGIPL LKSDEQLFET 1500 LEHNQVQLQT LLQSKYVEYF IEQVLSWQNK LNIADLVIFT WMEVQRTWSH LESIFVCSED 1560 IRIQLVKDAR RFDGVDAEFK ELMFKTAKVE NVLEATCRPN LYEKLKDLQS RLSLCEKALA 1620 EYLETKRIAF PRFYFVSSAD LLDILSKGAQ PKQVTCHLAK LFDSIADLQF EDNQDVSAHR 1680 AVGMYSKEKE YVPFQAECEC VGHVETWLLQ LEQTMQETVR HSITEAIVAY EEKPRELWIF 1740 DFPAQVALTS SQIWWTTDVG IAFSRLEEGY ETALKDFHKK QISQLNTLIT LLLGELPPGD 1800 RQKIMTICTI DVHARDVVAK LISQKQVVVS PQAFTWLSQL RHRWEDTQKH CFVNICDAQF 1860 QYFYEYLGNS PRLVITPLTD RCYITLTQSL HLTMSGAPAG PAGTGKTETT KDLGRALGMM 1920 VYVFNCSEQM DYKSIGNIYK GLVQTGAWGC FDEFNRISVE VLSVVAVQVK MIHDAIRNRK 1980 KRFVFLGEAI TLKPSVGIFI TMNPGYAGRT ELPENLKALF RPCAMVAPDI ELICEILLVA 2040 EGFVDARALA RKFITLYTLC KELLSKQDHY DWGLRAIKSV LVVAGSLKRG DKNRPEDQVL 2100 MRALRDFNMP KIVTDDIPVF LGLVGDLFPA LDVPRRRKLH FEQMVRQSTL ELRLQPEESF 2160 ILKVVQLEEL LAVRHSVFVV GNAGTGKSKI LRTLNRTYVN MKQKPVWNDL NPKAVTTDEL 2220 FGFIHHATRE WKDGKIVYSY FIGLFSSILR EQANLKHDGP KWIVLDGDID PMWIESLNTV 2280 MDDNKVLTLA SNERIALTPF MRLLFEIHHL RSATPATVSR AGILYVNPQD LGWNPYVASW 2340 IDRRRHQSEK ANLTILFDKY VPACLDKLRT SFKTITSIPE SSLVQTLCVL LECLLTPENV 2400 PSDSPKEVYE VYFVFACIWA FGGTLLQDQI SDYQADFSRW WQKEMKAVKF PSQGTIFDYY 2460 VDHKTKKLLP WADKIAQFTM DPDVPLQTVL VHTTETARLR YFMELLLEKG KPLMLVGNAG 2520 VGKTVFVGDT LASLSEDYIV SRVPFNYYTT STALQKILEK PLEKKAGHNY GPGGNKKLIY 2580 FIDDMNMPEV DLYGTVQPHT LIRQHIDYGH WYDRQKVMLK EIHNCQYVAC MNPMVGSFTI 2640 SPRLQRHFTV FAFNFPSLDA LNTIYGQIFS FHFQQQAFAP SILRSGPTLI QATIAFHQTM 2700 MCNFLPTAIK FHYIFNLRDL SNVFQGILFA SPECLKGPLD LIHLWLHESA RVYGDKLIDK 2760 KDCDLFQRRM LETAYKYFEG IDSHMLLQQP LIYCHFADRG KDPHYMPVKD WEVLKTILTE 2820 TLDNYNELNA AMHLVLFEDA MQHVCRISRI LRTPQGCALL VGVGGSGKQS LSRLAAYLRG 2880 LEVFQITLTE GYGIQELRVD LANLYIRTGA KNMPTVFLLT DAQVLDESFL VLINDLLASG 2940 EIPDLFSDED VDKIISGIHN EVHALGMVDS RENCWKFFMA RVRLQLKIIL CFSPVGRTLR 3000 VRARKFPAIV NCTAIDWFHA WPQEALVSVS RRFIEETKGI EPVHKDSISL FMAHVHTTVN 3060 EMSTRYYQNE RRHNYTTPKS FLEQISLFKN LLKKKQNEVS EKKERLVNGI QKLKTTASQV 3120 GDLKARLASQ EAELQLRNHD AEALITKIGL QTEKVSREKT IADAEERKVT AIQTEVFQKQ 3180 RECEADLLKA EPALVAATAA LNTLNRVNLS ELKAFPNPPI AVTNVTAAVM VLLAPRGRVP 3240 KDRSWKAAKV FMGKVDDFLQ ALINYDKEHI PENCLKVVNE HYLKDPEFNP NLIRTKSFAA 3300 AGLCAWVINI IKFYEVYCDV EPKRQALAQA NLELAAATEK LEAIRKKLVD LDRNLSRLTA 3360 SFEKATAEKV RCQEEVNQTN KTIKLANRLV KELEAKKIRW GQSIKSFEAQ EKTLCGDVLL 3420 TAAFVSYVGP FTRQYRQELV HCKWVPFLQQ KVSIPLTEGL DLISMLTDDA TIAAWNNEGL 3480 PSDRMSTENA AILTHCERWP LVIDPQQQGI KWIKNKYGMD LKVTHLGQKG FLNAIETALA 3540 FGDVILIENL EETIDPVLDP LLGRNTIKKG KYIRIGDKEC EFNKNFRLIL HTKLANPHYK 3600 PELQAQTTLL NFTVTEDGLE AQLLAEVVSI ERPDLEKLKL VLTKHQNDFK IELKYLEDDL 3660 LLRLSAAEGS FLDDTKLVER LEATKTTVAE IEHKVIEAKE NERKINEARE CYRPLAARAS 3720 LLYFVINDLQ KINPLYQFSL KAFNVLFHRA IEQADKVEDM QGRISILMES ITHAVFLYTS 3780 QALFEKDKLT FLSQMAFQIL LRKKEIDPLE LDFLLRFTVE HTHLSPVDFL TSQSWSAIKA 3840 IAVMEEFRGI DRDVEGSAKQ WRKWVESECP EKEKLPQEWK KKSLIQKLIL LRAMRPDRMT 3900 YALRNFVEEK LGAKYVERTR LDLVKAFEES SPATPIFFIL SPGVDALKDL EILGKRLGFT 3960 IDSGKFHNVS LGQGQETVAE VALEKASKGG HWVILQNVHL VAKWLGTLEK LLERFSQGSH 4020 RDYRVFMSAE SAPTPDEHII PQGLLENSIK ITNEPPTGML ANLHAALYNF DQDTLEICSK 4080 EQEFKSILFS LCYFHACVAG RLRFGPQGWS RSYPFNPGDL TICASVLYNY LEANSKVPWE 4140 DLRYLFGEIM YGGHITDDWD RKLCRVYLEE FMNPSLTEDE LMLAPGFAAP PYLDYAGYHQ 4200 YIEEMLPPES PALYGLHPNA EIEFLTVTSN TLFRTLLEMQ PRNALSGDEL GQSTEEKVKN 4260 VLDDILEKLP EEFNMAEIMQ KNSNRSPYVL VCFQECERMN ILIREIRISL EQLDLSLKGE 4320 LALSPAVEAQ QFALSYDTVP DTWSKLAYPS TYGLAQWFND LLLRCRELDT WTQDLTLPAV 4380 VWLSGFFNPQ SFLTAIMQTM ARKNEWPLDK TRLTADVTKK TKEDYGHPPR EGAYLHGLFM 4440 EGARWDTQAG TIVEARLKEL ACPMPVIFAK ATPVDRQETK QTYECPVYRT KLRGPSYIWT 4500 FRLKSEEKTA KWVLAGVALL LEA 4523 |
Gene Ontology | GO:0005858; C:axonemal dynein complex; NAS:UniProtKB. GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IEA:InterPro. GO:0003777; F:microtubule motor activity; NAS:UniProtKB. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0001539; P:ciliary or flagellar motility; IEA:Compara. GO:0007368; P:determination of left/right symmetry; IEA:Compara. GO:0007018; P:microtubule-based movement; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |