CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein squid 
Protein Synonyms/Alias
 Heterogeneous nuclear ribonucleoprotein 40; HNRNP 40 
Gene Name
 sqd 
Gene Synonyms/Alias
 hrp40; CG16901 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
78ELRDHFGKYGEIESIacetylation[1]
204PKQKIAGKEVDVKRAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. At least one of the isoforms is essential in somatic tissues. 
Sequence Annotation
 DOMAIN 56 138 RRM 1.
 DOMAIN 136 213 RRM 2.
 MOD_RES 148 148 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 344 AA 
Protein Sequence
MAENKQVDTE INGEDFTKDV TADGPGSENG DAGAAGSTNG SSDNQSAASG QRDDDRKLFV 60
GGLSWETTEK ELRDHFGKYG EIESINVKTD PQTGRSRGFA FIVFTNTEAI DKVSAADEHI 120
INSKKVDPKK AKARHGKIFV GGLTTEISDE EIKTYFGQFG NIVEVEMPFD KQKSQRKGFC 180
FITFDSEQVV TDLLKTPKQK IAGKEVDVKR ATPKPENQMM GGMRGGPRGG MRGGRGGYGG 240
RGGYNNQWDG QGSYGGYGGG YGGYGAGGYG DYYAGGYYNG YDYGYDGYGY GGGFEGNGYG 300
GGGGGNMGGG RGGPRGGGGP KGGGGFNGGK QRGGGGRQQR HQPY 344 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IDA:FlyBase.
 GO:0000785; C:chromatin; IDA:FlyBase.
 GO:0005737; C:cytoplasm; TAS:FlyBase.
 GO:0035062; C:omega speckle; IDA:FlyBase.
 GO:0005703; C:polytene chromosome puff; IDA:FlyBase.
 GO:0071011; C:precatalytic spliceosome; IDA:FlyBase.
 GO:0003730; F:mRNA 3'-UTR binding; TAS:FlyBase.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008069; P:dorsal/ventral axis specification, ovarian follicular epithelium; IMP:FlyBase.
 GO:0006406; P:mRNA export from nucleus; NAS:FlyBase.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:FlyBase.
 GO:0033119; P:negative regulation of RNA splicing; IMP:FlyBase.
 GO:0017148; P:negative regulation of translation; TAS:FlyBase.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:FlyBase.
 GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IMP:FlyBase.
 GO:0016325; P:oocyte microtubule cytoskeleton organization; IMP:FlyBase.
 GO:0007297; P:ovarian follicle cell migration; IMP:FlyBase.
 GO:0045451; P:pole plasm oskar mRNA localization; IEP:FlyBase.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:FlyBase. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS