| Tag | Content |
|---|
| CPLM ID | CPLM-018696 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 40 member 1 |
Protein Synonyms/Alias | CAR1; Cell adhesion regulator; Ferroportin-1 |
Gene Name | Slc40a1 |
Gene Synonyms/Alias | Fpn1; Fpt1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 253 | LKQLTSPKDTEPKPL | ubiquitination | [1] |
|
Reference | [1] Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J. EMBO J. 2007 Jun 20;26(12):2823-31. [ PMID: 17541408] |
Functional Description | May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin) (By similarity). |
Sequence Annotation | |
Keyword | Cell membrane; Complete proteome; Ion transport; Iron; Iron transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 570 AA |
Protein Sequence | MTKSRDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNGLLL 60
TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKNEL 120
LNMYHGWVLT VCYILIITIA NIANLASTAT AITIQRDWIV VVAGENRSRL ADMNATIRRI 180
DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK 240
VEESELKQLT SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQIAE PFRTFRDGWV 300
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSVLMGASA ITGIMGTVAF 360
TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFIHEEAVSS 420
TTKIPETEML MSNVSNVVNT VHEMSTKSVP IISVSLLFAG VIAARIGLWS FDLTVTQLLQ 480
ENVIESERGI INGVQNSMNY LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF 540
AQKTLGNQIF VCAPDEKEVT DESQPNTSVV 570 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005381; F:iron ion transmembrane transporter activity; NAS:RGD. GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |