CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025837
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 4 gamma, 3 variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1089RRSIGNIKFIGELFKubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Initiation factor; Protein biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1780 AA 
Protein Sequence
VKKIHRHRLS PATEKGAASS GEGDKDPPPP AHEDIAVKGT ATAAGTGPGT GAAAAAAAAV 60
PPPHPAAAAA AAAAAAAAAA AVPPPHPNIR ALQTQAPQQI PRGPVQQPLE DRIFTPAVSA 120
VYSTVTQVAR QPGTPTPSPY SAHEINKGHP NLAATPPGHA SSPGLSQTPY PSGQNAGPTT 180
LVYPQTPQTM NSQPQTRSPG GFRPIQFFQR PQIQPPRATI PNSSPSIRPG AQTPTAVYQA 240
NQHIMMVNHL PMPYPVPQGP QYCIPQYRHS GPPYVGPPQQ YPVQPPGPGP FYPGPGPGDF 300
PNAYGTPFYP SQPVYQSAPI IVPTQQQPPP AKREKKTIRI RDPNQGGKDI TEEIMSGGGS 360
RNPTPPIGRP TSTPTPPQLP SQVPEHSPVV YGTVESAHLA ASTPVTAASD QKQEEKPKPD 420
PVLKSPSPVL RLVLSGEKKE QEGQTSETTA IVSIAELPLP PSPTTVSSVA RSTIAAPTSS 480
ALSSQPIFTT AIDDRCELSS PREDTIPIPS LTSCTETSDP LPTNENDDDI CKKPCSVAPN 540
DIPLVSSTNL INEINGVSEK LSATESIVEI VKQEVLPLTL ELEILENPPE EMKLECIPAP 600
ITPSTVPSFP PTPPTPPASP PHTPVIVPAA ATTVSSPSAA ITVQRVLEED ESIRTCLSED 660
AKEIQNKIEV EADGQTEEIL DSQNLNSRRS PVPAQIAITV PKTWKKPKDR TRTTEEMLEA 720
ELELKAEEEL SIDKVLESEQ DKMSQGFHPE RDPSDLKKVK AVEENGEEAE PVRNGAESVS 780
EGEGIDANSG STDSSGDGVT FPFKPESWKP TDTEGKKQYD REFLLDFQFM PACIQKPEGL 840
PPISDVVLDK INQPKLPMRT LDPRILPRGP DFTPAFADFG RQTPGGRGVP LLNVGSRRSQ 900
PGQRREPRKI ITVSVKEDVH LKKAENAWKP SQKRDSQADD PENIKTQELF RKVRSILNKL 960
TPQMFNQLMK QVSGLTVDTE ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD 1020
KPGNTVNFRK LLLNRCQKEF EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA 1080
RRRSIGNIKF IGELFKLKML TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA 1140
KPRMDQYFNQ MEKIVKERKT SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI 1200
EEQEEQRKVQ QLMTKEKRRP GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ 1260
LVPKAQLGSW GKGSSGGAKA SETDALRSSA SSLNRFSALQ PPAPSGSTPS TPVEFDSRRT 1320
LTSRGSMGRE KNDKPLPSAT ARPNTFMRGG SSKDLLDNQS QEEQRREMLE TVKQLTGGVD 1380
VERNSTEAER NKTRESAKPE ISAMSAHDKA ALSEEELERK SKSIIDEFLH INDFKEAMQC 1440
VEELNAQGLL HVFVRVGVES TLERSQITRD HMGQLLYQLV QSEKLSKQDF FKGFSETLEL 1500
ADDMAIDIPH IWLYLAELVT PMLKEGGISM RELTIEFSKP LLPVGRAGVL LSEILHLLCK 1560
QMSHKKVGAL WREADLSWKD FLPEGEDVHN FLLEQKLDFI ESDSPCSSEA LSKKELSAEE 1620
LYKRLEKLII EDKANDEQIF DWVEANLDEI QMSSPTFLRA LMTAVCKAAI IADSSTFRVD 1680
TAVIKQRVPI LLKYLDSDTE KELQALYALQ ASIVKLDQPA NLLRMFFDCL YDEEVISEDA 1740
FYKWESSKDP AEQNGKGVAL KSVTAFFTWL REAEEESEDN 1780 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0045727; P:positive regulation of translation; IEA:Compara.
 GO:0016070; P:RNA metabolic process; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3.
 IPR003307; W2_domain. 
Pfam
 PF02847; MA3
 PF02854; MIF4G
 PF02020; W2 
SMART
 SM00515; eIF5C
 SM00544; MA3
 SM00543; MIF4G 
PROSITE
 PS51366; MI
 PS51363; W2 
PRINTS