CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005178
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor-type tyrosine-protein phosphatase epsilon 
Protein Synonyms/Alias
 Protein-tyrosine phosphatase epsilon; R-PTP-epsilon 
Gene Name
 PTPRE 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
226WRMVWEQKSATIVMLmethylation[1]
237IVMLTNLKERKEEKCmethylation[1]
453GNLPANMKKARVIQIubiquitination[2]
454NLPANMKKARVIQIIubiquitination[3]
651SNILERVKAEGLLDVubiquitination[3]
663LDVFQAVKSLRLQRPubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). 
Sequence Annotation
 DOMAIN 135 394 Tyrosine-protein phosphatase 1.
 DOMAIN 426 689 Tyrosine-protein phosphatase 2.
 REGION 335 341 Substrate binding (By similarity).
 ACT_SITE 335 335 Phosphocysteine intermediate (By
 ACT_SITE 630 630 Phosphocysteine intermediate (By
 BINDING 303 303 Substrate (By similarity).
 BINDING 379 379 Substrate (By similarity).
 MOD_RES 696 696 Phosphotyrosine.
 CARBOHYD 23 23 N-linked (GlcNAc...) (Potential).
 CARBOHYD 30 30 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Alternative initiation; Alternative promoter usage; Cell membrane; Complete proteome; Cytoplasm; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
MEPLCPLLLV GFSLPLARAL RGNETTADSN ETTTTSGPPD PGASQPLLAW LLLPLLLLLL 60
VLLLAAYFFR FRKQRKAVVS TSDKKMPNGI LEEQEQQRVM LLSRSPSGPK KYFPIPVEHL 120
EEEIRIRSAD DCKQFREEFN SLPSGHIQGT FELANKEENR EKNRYPNILP NDHSRVILSQ 180
LDGIPCSDYI NASYIDGYKE KNKFIAAQGP KQETVNDFWR MVWEQKSATI VMLTNLKERK 240
EEKCHQYWPD QGCWTYGNIR VCVEDCVVLV DYTIRKFCIQ PQLPDGCKAP RLVSQLHFTS 300
WPDFGVPFTP IGMLKFLKKV KTLNPVHAGP IVVHCSAGVG RTGTFIVIDA MMAMMHAEQK 360
VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT ELDVSSLEKH LQTMHGTTTH 420
FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA NMKKARVIQI IPYDFNRVIL SMKRGQEYTD 480
YINASFIDGY RQKDYFIATQ GPLAHTVEDF WRMIWEWKSH TIVMLTEVQE REQDKCYQYW 540
PTEGSVTHGE ITIEIKNDTL SEAISIRDFL VTLNQPQARQ EEQVRVVRQF HFHGWPEIGI 600
PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV KAEGLLDVFQ 660
AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK 700 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.
 GO:0033003; P:regulation of mast cell activation; IEA:Compara.
 GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; IEA:Compara. 
Interpro
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt.
 IPR016336; Tyr_Pase_rcpt_a/e-type. 
Pfam
 PF00102; Y_phosphatase 
SMART
 SM00194; PTPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.