CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026543
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
3*****MGKGFGLLRKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MGKGFGLLRK TCQSVVANPQ QHSALEEEKN MKRKRVLSRE LCSAWDRPHG FVGLHNIGQT 60
CCLNSLIQVF MMNVDFRMVL KRITVPRGAE EQKRSVPFQL LLLLEKMQDS RQKAVLPTEL 120
VQCLQKYNVP LFVQHDAAHL FLTIWNLTKD QITDIDLAER LQDLFTIWTE ESLMCVGCGA 180
ESSRRGKLLT LSLPLFDMDS KPLKTLEDAL RCFFQPKELA SSDKCFCETC GKKTPCKQAQ 240
KLTGFPQTLT IHLMRFSVRN SQTVKICHSV YFPQSLDFSQ ILPTTDQSEI HYELFAVIAH 300
VGMADFGHYC AYIRNPVDGE WFCFNDSHVC WVTWKDVQCT YGDHIYRWRE TAYLLVYMKT 360
GS 362 
Gene Ontology
 GO:0019785; F:ISG15-specific protease activity; IEA:Compara.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0032020; P:ISG15-protein conjugation; IEA:Compara.
 GO:0035634; P:response to stilbenoid; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS