UniProt Accession

 CHMP6_HUMAN; Q96FZ7; A8K7U0; Q53FU4; Q9HAE8 

Genbank Protein ID

 AY329087; AK021811; CR457284; AK223187; AK292105; BC010108 

Genbank Nucleotide ID

 AAQ91196.1; BAB13901.1; CAG33565.1; BAD96907.1; BAF84794.1; AAH10108.1 

Protein Name

 Charged multivesicular body protein 6 

Protein Synonyms/Alias

 Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20 

Gene Name

 CHMP6 

Gene Synonyms/Alias

 VPS20 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	SRVTEQDKAILQLKQ	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. 

Sequence Annotation

 REGION 170 181 Interaction with VPS4A.
 MOTIF 168 179 Type-2 MIT-interacting motif.
 LIPID 2 2 N-myristoyl glycine (Probable).  

Keyword

 3D-structure; Coiled coil; Complete proteome; Endosome; Lipoprotein; Membrane; Myristate; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0016197; P:endosomal transport; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR005024; Snf7. 

Pfam

 PF03357; Snf7 

SMART

  

PROSITE

  

PRINTS