UniProt Accession

 ORML2_HUMAN; Q53FV1; B2RA58; Q7Z4E5; Q8NFX0; Q9P004 

Genbank Protein ID

 AF395705; AF395706; AF395707; AB064961; AF161509; AF173375; AK223180; AK314046; CH471054; BC012543 

Genbank Nucleotide ID

 AAM43504.1; AAM43505.1; AAM43506.1; BAC11712.1; AAF29124.1; AAQ13618.1; BAD96900.1; BAG36755.1; EAW96840.1; AAH12543.1 

Protein Name

 ORM1-like protein 2 

Protein Synonyms/Alias

 Adoplin-2 

Gene Name

 ORMDL2 

Gene Synonyms/Alias

 HSPC160; MSTP095 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	FETPDQGKARLLTHW	ubiquitination	[1]
152	VRVFGINKY******	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Negative regulator of sphingolipid synthesis. 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006672; P:ceramide metabolic process; IMP:UniProtKB. 

Interpro

 IPR007203; ORMDL. 

Pfam

 PF04061; ORMDL 

SMART

  

PROSITE

  

PRINTS