| Tag | Content |
|---|
| CPLM ID | CPLM-018197 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 4A |
Protein Synonyms/Alias | |
Gene Name | Vps4a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 51 | KYEAHSDKAKESIRA | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis (By similarity). |
Sequence Annotation | DOMAIN 2 80 MIT.
NP_BIND 167 174 ATP (Potential).
MOD_RES 2 2 N-acetylthreonine (By similarity).
MOD_RES 8 8 N6-acetyllysine (By similarity). |
Keyword | Acetylation; ATP-binding; Cell cycle; Cell division; Coiled coil; Complete proteome; Endosome; Hydrolase; Membrane; Nucleotide-binding; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 437 AA |
Protein Sequence | MTTSTLQKAI DLVTKATEED KAKNYEEALR LYQHAVEYFL HAIKYEAHSD KAKESIRAKC 60
MQYLDRAEKL KDYLRNKEKH GKKPVKENQS EGKGSDSDSE GDNPEKKKLQ EQLMGAVVME 120
KPNIRWNDVA GLEGAKEALK EAVILPIKFP HLFTGKRTPW RGILLFGPPG TGKSYLAKAV 180
ATEANNSTFF SVSSSDLMSK WLGESEKLVK NLFELARQHK PSIIFIDEVD SLCGSRNENE 240
SEAARRIKTE FLVQMQGVGN NNDGTLVLGA TNIPWVLDSA IRRRFEKRIY IPLPEEAARA 300
QMFRLHLGST PHNLTDANIH ELARKTEGYS GADISIIVRD SLMQPVRKVQ SATHFKKVCG 360
PSRTNPSVMI DDLLTPCSPG DPGAIEMTWM DVPGDKLLEP VVCMSDMLRS LATTRPTVNA 420
DDLLKVKKFS EDFGQES 437 |
Gene Ontology | GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |