CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020915
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 39S ribosomal protein L12, mitochondrial 
Protein Synonyms/Alias
 L12mt; MRP-L12 
Gene Name
 Mrpl12 
Gene Synonyms/Alias
 Rpml12 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
141TVRLTEAKPVDKVKLacetylation[1, 2, 3]
145TEAKPVDKVKLIKEIacetylation[2, 4]
147AKPVDKVKLIKEIKNacetylation[4]
150VDKVKLIKEIKNYVQacetylation[2]
153VKLIKEIKNYVQGINacetylation[3, 5, 6]
153VKLIKEIKNYVQGINsuccinylation[6]
165GINLVQAKKLVESLPacetylation[2, 3, 6]
165GINLVQAKKLVESLPsuccinylation[6]
166INLVQAKKLVESLPQacetylation[6]
166INLVQAKKLVESLPQsuccinylation[6]
181EIKANVAKAEAEKIKacetylation[3, 6]
181EIKANVAKAEAEKIKsuccinylation[6]
186VAKAEAEKIKAALEAacetylation[2, 4]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 201 AA 
Protein Sequence
MLPVAASRCL WGPRLGLRGA ALRLARQQMP SVCAARQLRS SSHRRSEALA GAPLDNAPKE 60
YPPKIQQLVQ DIASLTLLEI SDLNELLKKT LKIQDVGLMP MGGMVPGPVS AAAPASEAAE 120
EEDVPKQKER THFTVRLTEA KPVDKVKLIK EIKNYVQGIN LVQAKKLVES LPQEIKANVA 180
KAEAEKIKAA LEAVGGTVVL E 201 
Gene Ontology
 GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006390; P:transcription from mitochondrial promoter; IEA:Compara.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR015607; Ribosomal_L12_mit.
 IPR014719; Ribosomal_L7/12_C/ClpS-like.
 IPR013823; Ribosomal_L7/L12_C.
 IPR008932; Ribosomal_L7/L12_oligo. 
Pfam
 PF00542; Ribosomal_L12 
SMART
  
PROSITE
  
PRINTS