UniProt Accession

 RSMB_MOUSE; P27048; Q3UJT1 

Genbank Protein ID

 M58761; AK146319 

Genbank Nucleotide ID

 AAA40119.1; BAE27074.1 

Protein Name

 Small nuclear ribonucleoprotein-associated protein B 

Protein Synonyms/Alias

 snRNP-B; snRPB; Sm protein B; Sm-B; SmB 

Gene Name

 Snrpb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	RIFIGTFKAFDKHMN	ubiquitination	[1]
88	TVEGPPPKDTGIARV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Associated with snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. 

Sequence Annotation

 REPEAT 175 181
 REPEAT 191 196
 REPEAT 216 221
 REPEAT 222 228
 REGION 175 228 Repeat-rich region.
 MOD_RES 108 108 Omega-N-methylated arginine (By
 MOD_RES 112 112 Dimethylated arginine; alternate (By
 MOD_RES 112 112 Omega-N-methylated arginine; alternate
 MOD_RES 147 147 Omega-N-methylarginine (By similarity).  

Keyword

 Complete proteome; Methylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0071204; C:histone pre-mRNA 3'end processing complex; IDA:UniProtKB.
 GO:0005689; C:U12-type spliceosomal complex; IEA:Compara.
 GO:0005683; C:U7 snRNP; ISS:UniProtKB.
 GO:0071208; F:histone pre-mRNA DCP binding; IDA:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc.
 IPR017131; snRNP-assoc_SmB/SmN. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS