UniProt Accession

 SMN_HUMAN; Q16637; A8K0V4; Q13119; Q549U5; Q96J51 

Genbank Protein ID

 U43883; U43876; U43877; U43878; U43880; U43881; U43882; U18423; U80017; AK289669; AC004999; AC005031; U21914; BC000908; BC015308; BC062723; BC070242 

Genbank Nucleotide ID

 AAC50473.1; AAC50473.1; AAC50473.1; AAC50473.1; AAC50473.1; AAC50473.1; AAC50473.1; AAA66242.1; AAC52048.1; BAF82358.1; AAC83178.1; AAC62262.1; AAA64505.1; AAH00908.1; AAH15308.1; AAH62723.1; AAH70242.1 

Protein Name

 Survival motor neuron protein 

Protein Synonyms/Alias

 Component of gems 1; Gemin-1 

Gene Name

 SMN1; SMN2 

Gene Synonyms/Alias

 SMN; SMNT; SMNC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	WDDTALIKAYDKAVA	ubiquitination	[1, 2, 3]
51	DKAVASFKHALKNGD	ubiquitination	[1, 3]
186	KSDNIKPKSAPWNSF	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. 

Sequence Annotation

 DOMAIN 91 151 Tudor.
 REGION 13 44 P1 (binding site for GEMIN2).
 REGION 240 267 P2 (binding site for SM B).
 REGION 279 294 Required for interaction with SYNCRIP.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 4 4 Phosphoserine; by PKA.
 MOD_RES 5 5 Phosphoserine; by PKA.
 MOD_RES 8 8 Phosphoserine; by PKA.
 MOD_RES 25 25 Phosphothreonine.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 31 31 Phosphoserine.
 MOD_RES 85 85 Phosphothreonine; by PKA.
 MOD_RES 187 187 Phosphoserine; by PKA.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; mRNA processing; mRNA splicing; Neurodegeneration; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; NAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0000245; P:spliceosomal complex assembly; NAS:UniProtKB.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:Reactome. 

Interpro

 IPR010304; Survival_motor_neuron.
 IPR002999; Tudor. 

Pfam

 PF06003; SMN 

SMART

 SM00333; TUDOR 

PROSITE

 PS50304; TUDOR 

PRINTS