UniProt Accession

 KCAB2_HUMAN; Q13303; A0AVM9; A8K1A4; B0AZR7; O43659; Q5TG82; Q5TG83; Q6ZNE4; Q99411 

Genbank Protein ID

 U33429; AF029749; AF044253; AK124696; AK131252; AK289819; AK315858; AL035406; AL035406; BC126424; BC130413 

Genbank Nucleotide ID

 AAC50955.1; AAB84170.1; AAB99859.1; BAG54071.1; BAD18431.1; BAF82508.1; BAF98749.1; CAC08512.1; CAI19885.1; AAI26425.1; AAI30414.1 

Protein Name

 Voltage-gated potassium channel subunit beta-2 

Protein Synonyms/Alias

 K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2 

Gene Name

 KCNAB2 

Gene Synonyms/Alias

 KCNA2B; KCNK2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
138	VLGNIIKKKGWRRSS	ubiquitination	[1]
157	TKIFWGGKAETERGL	ubiquitination	[1]
167	TERGLSRKHIIEGLK	ubiquitination	[1]
272	YHMFQREKVEVQLPE	ubiquitination	[1]
316	PYSRASLKGYQWLKD	ubiquitination	[1, 2]
322	LKGYQWLKDKILSEE	ubiquitination	[1]
324	GYQWLKDKILSEEGR	ubiquitination	[1]
338	RRQQAKLKELQAIAE	ubiquitination	[1, 2]
406	IDSILGNKPYSKKDY	ubiquitination	[1]
410	LGNKPYSKKDYRS**	ubiquitination	[1]
411	GNKPYSKKDYRS***	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.4. 

Sequence Annotation

 NP_BIND 56 57 NADP.
 NP_BIND 188 189 NADP.
 NP_BIND 243 248 NADP.
 NP_BIND 323 329 NADP.
 BINDING 63 63 NADP.
 BINDING 85 85 NADP.
 BINDING 90 90 NADP.
 BINDING 214 214 NADP.
 BINDING 254 254 NADP.
 MOD_RES 9 9 Phosphoserine.
 MOD_RES 20 20 Phosphoserine (By similarity).
 MOD_RES 25 25 Phosphotyrosine (By similarity).
 MOD_RES 124 124 N6-acetyllysine.
 MOD_RES 360 360 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Ion channel; Ion transport; NADP; Phosphoprotein; Polymorphism; Potassium; Potassium transport; Reference proteome; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0044224; C:juxtaparanode region of axon; ISS:BHF-UCL.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015459; F:potassium channel regulator activity; TAS:ProtInc.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR005983; K_chnl_volt-dep_bsu_KCNAB.
 IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
 IPR005401; K_chnl_volt-dep_bsu_KCNAB2.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS

 PR01579; KCNAB2CHANEL.
 PR01577; KCNABCHANNEL.