UniProt Accession

 VAMP4_MOUSE; O70480; Q9D095 

Genbank Protein ID

 AF061516; AK011678; AK018344 

Genbank Nucleotide ID

 AAC15776.1; BAB27774.1; BAB31171.1 

Protein Name

 Vesicle-associated membrane protein 4 

Protein Synonyms/Alias

 VAMP-4 

Gene Name

 Vamp4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	DDVTGSVKSERRNLL	ubiquitination	[1]
87	RLDELQDKSESLSDN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). 

Sequence Annotation

 DOMAIN 52 112 v-SNARE coiled-coil homology.
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 30 30 Phosphoserine.  

Keyword

 3D-structure; Coiled coil; Complete proteome; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031201; C:SNARE complex; IDA:MGI.
 GO:0005802; C:trans-Golgi network; IDA:MGI.
 GO:0043001; P:Golgi to plasma membrane protein transport; IMP:MGI.
 GO:0042996; P:regulation of Golgi to plasma membrane protein transport; IMP:MGI. 

Interpro

 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 

Pfam

 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.