UniProt Accession

 SFR1_MOUSE; Q8BP27; Q3TH62; Q3TI03; Q3TJK0; Q3UIQ6; Q8R3W0; Q9CRT7; Q9D0D7; Q9D116; Q9D4W4 

Genbank Protein ID

 AK004073; AK011531; AK014266; AK016079; AK077875; AK078147; AK146810; AK167406; AK168068; AK168427; BC024403 

Genbank Nucleotide ID

 BAB23154.1; BAB27680.1; BAB29232.1; BAB30105.1; BAC37045.1; BAC37148.1; BAE27450.1; BAE39495.1; BAE40043.1; BAE40336.1; AAH24403.1 

Protein Name

 Swi5-dependent recombination DNA repair protein 1 homolog 

Protein Synonyms/Alias

 Meiosis protein 5 homolog 

Gene Name

 Sfr1 

Gene Synonyms/Alias

 Mei5; Meir5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
149	HSFCSVVKRMKVEND	acetylation	[1, 2, 3]
255	LVKMYRIKNDVTELE	ubiquitination	[4]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. 

Sequence Annotation

 MOD_RES 99 99 Phosphoserine.
 MOD_RES 103 103 Phosphoserine.
 MOD_RES 115 115 Phosphoserine.
 MOD_RES 140 140 Phosphoserine (By similarity).
 MOD_RES 163 163 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0032798; C:Swi5-Sfr1 complex; IDA:UniProtKB.
 GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB. 

Interpro

 IPR018468; Ds-recomb_repair_prot_Mei5. 

Pfam

 PF10376; Mei5 

SMART

  

PROSITE

  

PRINTS