UniProt Accession

 CAPZA_DROME; Q9W2N0 

Genbank Protein ID

 AE013599; AY069084 

Genbank Nucleotide ID

 AAF46660.1; AAL39229.1 

Protein Name

 F-actin-capping protein subunit alpha 

Protein Synonyms/Alias

  

Gene Name

 cpa 

Gene Synonyms/Alias

 CG10540 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
281	IVSYSIGKELKTQ**	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). 

Sequence Annotation

  

Keyword

 Actin capping; Actin-binding; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:FlyBase.
 GO:0005869; C:dynactin complex; ISS:FlyBase.
 GO:0008290; C:F-actin capping protein complex; IEA:InterPro.
 GO:0007015; P:actin filament organization; IMP:FlyBase.
 GO:0051016; P:barbed-end actin filament capping; ISS:FlyBase.
 GO:0000902; P:cell morphogenesis; IMP:FlyBase.
 GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase.
 GO:0007018; P:microtubule-based movement; ISS:FlyBase.
 GO:0051490; P:negative regulation of filopodium assembly; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0010591; P:regulation of lamellipodium assembly; IMP:FlyBase.
 GO:0035220; P:wing disc development; IMP:FlyBase. 

Interpro

 IPR017865; F-actin_cap_asu_CS.
 IPR002189; WASH_F-actin_cap_alpha. 

Pfam

 PF01267; F-actin_cap_A 

SMART

  

PROSITE

 PS00748; F_ACTIN_CAPPING_A_1
 PS00749; F_ACTIN_CAPPING_A_2 

PRINTS

 PR00191; FACTINCAPA.