UniProt Accession

 FIP1_HUMAN; Q6UN15; B4DIR3; G3XAD6; Q0VGE0; Q499Y4; Q49AU3; Q7Z608; Q8WVN3; Q96F80; Q9H077 

Genbank Protein ID

 AY366510; AL136910; AK295737; AC058822; AC095040; AC098587; AC098821; AC105384; AC110298; AC110792; AC124017; AC138607; AC138779; CH471057; BC011543; BC017724; BC024016; BC052959; BC110383; AY229892 

Genbank Nucleotide ID

 AAQ88277.1; CAB66844.1; BAG58575.1; EAX05448.1; AAH11543.1; AAH17724.1; AAH24016.1; AAH52959.1; AAI10384.1; AAP69563.1 

Protein Name

 Pre-mRNA 3'-end-processing factor FIP1 

Protein Synonyms/Alias

 hFip1; FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia 

Gene Name

 FIP1L1 

Gene Synonyms/Alias

 FIP1; RHE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	APVNLNIKTGGRVYG	ubiquitination	[1]
195	PVTSTTNKITVQQGR	ubiquitination	[2]
375	PSLVDTSKQWDYYAR	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. 

Sequence Annotation

 REGION 1 356 Necessary for stimulating PAPOLA
 REGION 1 111 Sufficient for interaction with PAPOLA.
 REGION 137 243 Sufficient for interaction with CPSF4.
 REGION 443 594 Sufficient for interaction with CPSF1 and
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 89 89 Phosphoserine.
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 294 294 N6-acetyllysine.
 MOD_RES 304 304 Phosphoserine.
 MOD_RES 426 426 Phosphotyrosine.
 MOD_RES 492 492 Phosphoserine.
 MOD_RES 494 494 Phosphothreonine.
 MOD_RES 496 496 Phosphoserine.
 MOD_RES 500 500 Phosphoserine.
 MOD_RES 554 554 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 594 AA 

Protein Sequence

Gene Ontology

 GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR007854; Fip1. 

Pfam

 PF05182; Fip1 

SMART

  

PROSITE

  

PRINTS