UniProt Accession

 AT1B1_HUMAN; P05026; Q5TGZ3 

Genbank Protein ID

 X03747; M25160; M25161; U16799; BT009787; AL031726; BC000006; X17161 

Genbank Nucleotide ID

 CAA27385.1; AAA36352.1; AAA36352.1; AAC50132.1; AAP88789.1; CAI18888.1; AAH00006.1; CAA35040.1 

Protein Name

 Sodium/potassium-transporting ATPase subunit beta-1 

Protein Synonyms/Alias

 Sodium/potassium-dependent ATPase subunit beta-1 

Gene Name

 ATP1B1 

Gene Synonyms/Alias

 ATP1B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	SFRPNDPKSYEAYVL	ubiquitination	[1]
248	QYYPYYGKLLQPKYL	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. 

Sequence Annotation

 REGION 191 303 immunoglobulin-like.
 MOD_RES 101 101 Phosphotyrosine (By similarity).
 CARBOHYD 158 158 N-linked (GlcNAc...).
 CARBOHYD 193 193 N-linked (GlcNAc...).
 CARBOHYD 265 265 N-linked (GlcNAc...).
 DISULFID 126 149 By similarity.
 DISULFID 159 175 By similarity.
 DISULFID 213 276 By similarity.  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005901; C:caveola; IEA:Compara.
 GO:0005890; C:sodium:potassium-exchanging ATPase complex; TAS:ProtInc.
 GO:0005391; F:sodium:potassium-exchanging ATPase activity; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0001666; P:response to hypoxia; IEA:Compara. 

Interpro

 IPR000402; Na/K_ATPase_sub_beta.
 IPR015565; Na/K_ATPase_sub_beta_chordates. 

Pfam

 PF00287; Na_K-ATPase 

SMART

  

PROSITE

 PS00390; ATPASE_NA_K_BETA_1
 PS00391; ATPASE_NA_K_BETA_2 

PRINTS