UniProt Accession

 LAMP2_MOUSE; P17047; A2A430; Q3TXG5; Q8BSG8 

Genbank Protein ID

 J05287; AK159272; AK032974; AK163933; AL513356; AL513356; CH466570; CH466570; BC138718; BC138723; M32017; M32018 

Genbank Nucleotide ID

 AAA39412.1; BAE34951.1; BAC28106.1; BAE37543.1; CAM17143.1; CAM17144.1; EDL29016.1; EDL29018.1; AAI38719.1; AAI38724.1; AAA39429.1; AAA39430.1 

Protein Name

 Lysosome-associated membrane glycoprotein 2 

Protein Synonyms/Alias

 LAMP-2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; Lysosomal membrane glycoprotein type B; LGP-B; CD107b 

Gene Name

 Lamp2 

Gene Synonyms/Alias

 Lamp-2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
140	VKNPENFKVPLDVIF	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. 

Sequence Annotation

 REGION 26 188 First lumenal domain.
 REGION 189 233 Hinge.
 REGION 234 379 Second lumenal domain.
 CARBOHYD 29 29 N-linked (GlcNAc...) (Potential).
 CARBOHYD 45 45 N-linked (GlcNAc...) (Potential).
 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
 CARBOHYD 175 175 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 234 234 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).
 CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).
 CARBOHYD 280 280 N-linked (GlcNAc...) (Potential).
 CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
 CARBOHYD 317 317 N-linked (GlcNAc...) (Potential).
 CARBOHYD 322 322 N-linked (GlcNAc...) (Potential).
 CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).
 DISULFID 37 75 By similarity.
 DISULFID 149 185 By similarity.
 DISULFID 237 270 By similarity.
 DISULFID 336 373 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Lysosome; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IDA:MGI.
 GO:0005765; C:lysosomal membrane; IDA:BHF-UCL.
 GO:0030670; C:phagocytic vesicle membrane; IMP:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0031088; C:platelet dense granule membrane; IEA:Compara. 

Interpro

 IPR018134; LAMP_CS.
 IPR002000; Lysosome-assoc_membr_glycop. 

Pfam

 PF01299; Lamp 

SMART

  

PROSITE

 PS00310; LAMP_1
 PS00311; LAMP_2
 PS51407; LAMP_3 

PRINTS

 PR00336; LYSASSOCTDMP.