CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018360
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat and SOCS box protein 15 
Protein Synonyms/Alias
 ASB-15 
Gene Name
 ASB15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
133NVRTLLEKGVWPNTKacetylation[1]
143WPNTKNDKGETPLLIacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). 
Sequence Annotation
 REPEAT 110 142 ANK 1.
 REPEAT 143 174 ANK 2.
 REPEAT 176 208 ANK 3.
 REPEAT 209 241 ANK 4.
 REPEAT 242 274 ANK 5.
 REPEAT 307 339 ANK 6.
 REPEAT 349 380 ANK 7.
 REPEAT 381 413 ANK 8.
 REPEAT 416 444 ANK 9.
 DOMAIN 524 579 SOCS box.  
Keyword
 ANK repeat; Complete proteome; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 588 AA 
Protein Sequence
MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA IKQGHIPELQ 60
EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY KTLWEFKTCD GETPLTLAVK 120
AGLVENVRTL LEKGVWPNTK NDKGETPLLI AVKKGSYDMV STLIKHNTSL DQPCVKRWSA 180
MHEAAKQGRK DIVALLLKHG GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA 240
DDGASVLFEA AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS 300
KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER KTALYFGVSN 360
NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL SHGANVNCYF MHVNDTRFPS 420
VIQYALNDEV MLRLLLNNGY QVEMCFDCMH GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP 480
FCEFITVPWM KHLVGRVTRV LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL 540
CRLKIRRLMG LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT 588 
Gene Ontology
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001496; SOCS_C. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF07525; SOCS_box 
SMART
 SM00248; ANK
 SM00969; SOCS_box 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50225; SOCS 
PRINTS
 PR01415; ANKYRIN.