| Tag | Content |
|---|
| CPLM ID | CPLM-023800 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
Protein Synonyms/Alias | dNTPase; Dendritic cell-derived IFNG-induced protein; DCIP; Monocyte protein 5; MOP-5; SAM domain and HD domain-containing protein 1 |
Gene Name | SAMHD1 |
Gene Synonyms/Alias | MOP5 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 66 | FEEPVLLKNIRENEI | ubiquitination | [1] | | 280 | LYEIVSNKRNGIDVD | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. |
Sequence Annotation | DOMAIN 45 110 SAM.
DOMAIN 164 319 HD.
NP_BIND 137 145 dGTP.
ACT_SITE 233 233 Probable.
METAL 167 167 Zinc.
METAL 206 206 Zinc.
METAL 207 207 Zinc.
METAL 311 311 Zinc.
BINDING 164 164 Substrate.
BINDING 210 210 Substrate.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 18 18 Phosphoserine (By similarity).
MOD_RES 21 21 Phosphothreonine (By similarity).
MOD_RES 25 25 Phosphothreonine (By similarity).
MOD_RES 592 592 Phosphothreonine. |
Keyword | 3D-structure; Acetylation; Aicardi-Goutieres syndrome; Alternative splicing; Antiviral defense; Complete proteome; Direct protein sequencing; Disease mutation; Hydrolase; Immunity; Innate immunity; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 626 AA |
Protein Sequence | MQRADSEQPS KRPRCDDSPR TPSNTPSAEA DWSPGLELHP DYKTWGPEQV CSFLRRGGFE 60
EPVLLKNIRE NEITGALLPC LDESRFENLG VSSLGERKKL LSYIQRLVQI HVDTPQFQRL 120
RYIKQLGGGY YVFPGASHNR FEHSLGVGYL AGCLVHALGE KQPELQISER DVLCVQIAGL 180
CHDLGHGPFS HMFDGRFIPL ARPEVKWTHE QGSVMMFEHL INSNGIKPVM EQYGLIPEED 240
ICFIKEQIVG PLESPVEDSL WPYKGRPENK SFLYEIVSNK RNGIDVDKWD YFARDCHHLG 300
IQNNFDYKRF IKFARVCEVD NELRICARDK EVGNLYDMFH TRNSLHRRAY QHKVGNIIDT 360
MITDAFLKAD DYIEITGAGG KKYRISTAID DMEAYTKLTD NIFLEILYST DPKLKDAREI 420
LKQIEYRNLF KYVGETQPTG QIKIKREDYE SLPKEVASAK PKVLLDVKLK AEDFIVDVIN 480
MDYGMQEKNP IDHVSFYCKT APNRAIRITK NQVSQLLPEK FAEQLIRVYC KKVDRKSLYA 540
ARQYFVQWCA DRNFTKPQDG DVIAPLITPQ KKEWNDSTSV QNPTRLREAS KSRVQLFKDD 600
PM 602 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro. GO:0003723; F:RNA binding; IDA:UniProtKB. GO:0051607; P:defense response to virus; IMP:UniProtKB. GO:0006955; P:immune response; NAS:UniProtKB. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0008152; P:metabolic process; IEA:GOC. GO:0045088; P:regulation of innate immune response; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |