CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030107
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitogen-activated protein kinase 14 
Protein Synonyms/Alias
  
Gene Name
 Mapk14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
248TPGAELLKKISSESDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGHRV AVKKLSRPFQ 60
SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 120
KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG 240
TPGAELLKKI SSESDAKP 258 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0000922; C:spindle pole; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004707; F:MAP kinase activity; IDA:MGI.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0000902; P:cell morphogenesis; IGI:MGI.
 GO:0002062; P:chondrocyte differentiation; IDA:MGI.
 GO:0000077; P:DNA damage checkpoint; IMP:MGI.
 GO:0019395; P:fatty acid oxidation; IMP:MGI.
 GO:0006006; P:glucose metabolic process; IMP:MGI.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:MGI.
 GO:0042307; P:positive regulation of protein import into nucleus; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0032495; P:response to muramyl dipeptide; IDA:MGI.
 GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
 GO:0051146; P:striated muscle cell differentiation; IGI:MGI. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR003527; MAP_kinase_CS.
 IPR008352; MAPK_p38.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS01351; MAPK
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 
PRINTS
 PR01773; P38MAPKINASE.