UniProt Accession

 ARC1B_MOUSE; Q9WV32; Q9CRC4 

Genbank Protein ID

 AF162768; AK002274; AK005378; AK147731; AK148145; AK159371; AK167978; AK168774; AK172124; CH466529; CH466529; BC003441 

Genbank Nucleotide ID

 AAD43352.1; BAB21980.1; BAB23985.1; BAE28101.1; BAE28373.1; BAE35028.1; BAE39970.1; BAE40610.1; BAE42835.1; EDL19001.1; EDL19002.1; AAH03441.1 

Protein Name

 Actin-related protein 2/3 complex subunit 1B 

Protein Synonyms/Alias

 Arp2/3 complex 41 kDa subunit; p41-ARC 

Gene Name

 Arpc1b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
82	NAYVWTLKGRTWKPT	acetylation	[1]
87	TLKGRTWKPTLVILR	acetylation	[1]
367	KSLESALKDLKIK**	acetylation	[2]
367	KSLESALKDLKIK**	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). 

Sequence Annotation

 REPEAT 6 45 WD 1.
 REPEAT 50 89 WD 2.
 REPEAT 94 135 WD 3.
 REPEAT 140 179 WD 4.
 REPEAT 242 280 WD 5.
 REPEAT 324 367 WD 6.
 MOD_RES 82 82 N6-acetyllysine (By similarity).
 MOD_RES 310 310 Phosphoserine.  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; TAS:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 

Interpro

 IPR017383; ARPC2/3_su1.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS