UniProt Accession

 GSTM1_MOUSE; P10649; A2AE90; Q58ET5 

Genbank Protein ID

 J03952; J04632; L13448; AL671877; AC079042; BC003822; BC046758; BC091763 

Genbank Nucleotide ID

 AAA37747.1; AAA37705.1; CAM17697.1; CAM17697.1; AAH03822.1; AAH46758.1; AAH91763.1 

Protein Name

 Glutathione S-transferase Mu 1 

Protein Synonyms/Alias

 GST 1-1; GST class-mu 1; Glutathione S-transferase GT8.7; pmGT10 

Gene Name

 Gstm1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
31	TDSSYDEKRYTMGDA	acetylation	[1]
31	TDSSYDEKRYTMGDA	ubiquitination	[2]
50	RSQWLNEKFKLGLDF	ubiquitination	[2]
52	QWLNEKFKLGLDFPN	ubiquitination	[2]
69	YLIDGSHKITQSNAI	ubiquitination	[2]
83	ILRYLARKHHLDGET	ubiquitination	[2]
122	CYNPDFEKQKPEFLK	acetylation	[3]
122	CYNPDFEKQKPEFLK	ubiquitination	[2]
124	NPDFEKQKPEFLKTI	acetylation	[1]
124	NPDFEKQKPEFLKTI	ubiquitination	[2]
129	KQKPEFLKTIPEKMK	acetylation	[1]
129	KQKPEFLKTIPEKMK	ubiquitination	[2]
136	KTIPEKMKLYSEFLG	ubiquitination	[2]
144	LYSEFLGKRPWFAGD	acetylation	[1]
144	LYSEFLGKRPWFAGD	ubiquitination	[2]
173	QYRMFEPKCLDAFPN	acetylation	[1]
173	QYRMFEPKCLDAFPN	ubiquitination	[2]
199	KKISAYMKSSRYIAT	ubiquitination	[2]
211	IATPIFSKMAHWSNK	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 2 88 GST N-terminal.
 DOMAIN 90 208 GST C-terminal.
 REGION 7 8 Glutathione binding (By similarity).
 REGION 46 50 Glutathione binding (By similarity).
 REGION 59 60 Glutathione binding (By similarity).
 REGION 72 73 Glutathione binding (By similarity).
 BINDING 116 116 Substrate (By similarity).
 MOD_RES 23 23 Phosphotyrosine.
 MOD_RES 33 33 Phosphotyrosine.
 MOD_RES 34 34 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004364; F:glutathione transferase activity; IEA:EC.
 GO:0046982; F:protein heterodimerization activity; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0035690; P:cellular response to drug; IDA:MGI. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003081; GST_mu.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01267; GSTRNSFRASEM.