CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038097
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium-dependent secretion activator 2 
Protein Synonyms/Alias
  
Gene Name
 Cadps2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
289GRLQLAEKMAKERRFubiquitination[1]
431PRPVVKVKLFTESTGubiquitination[1]
925DTLLCNGKFHKHLQEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1299 AA 
Protein Sequence
MLDPSSSEEE SDEGLEEESR EVLVAPGVSQ RAPPAAAREG RRDAPGRSGG GSGGGAARPV 60
SPSPSVLSEG RNEPELQLDE EQERRIRLQL YVFVVRCIAY PFNAKQPTDM ARRQQKLNKQ 120
QLQLLKERFQ AFLNGETQIV ADEAFCNAVR SYYEVFLKSD RVARMVQSGG CSANDFREVF 180
KKNIEKRVRS LPEIDGLSKE TVLSSWIAKY DAIYRGEEDL CKQPNRMTLS AVSELILSKE 240
QLYEMFQQIL GIKKLEHQLL YNACQLDNAD EQAAQIRREL DGRLQLAEKM AKERRFPRFI 300
SKEMESMYIE ELRASVNLLM ANLESLPVSK GGPEFKLQKL KRSQNSAFLD LGDENEIQLS 360
KSDVVLSFTL EIVIMEVQGL KSVAPNRIVY CTMEVEGGEK LQTDQAEASR PQWGTQGDFN 420
TTHPRPVVKV KLFTESTGVL ALEDKELGRV VLYPTSNSSK SAELHRMTVP KNSQDSDLKI 480
KLAVRMDKPA HMKHSGYLYA LGQKVWKRWK KRYFVLVQVS QYTFAMCSYR EKKSEPQELM 540
QLEGYTVDYT DPHPGLQGGQ VFFNAVKEGD TVIFASDDEQ DRILWVQAMY RATGQSYKPV 600
PAVQSQKLNP KGGALHADAQ LSFGFTDADR FQKHGMDEFI SASPCKLDHA FLFRILQRQT 660
LDHRLNDSYS CLGWFSPGQV FVLDEYCARY GVRGCHRHLC YLTELMEHSE NGAVIDPTLL 720
HYSFAFCASH VHGNRPDGIG TVSVEEKERF EEIKDRLSSL LENQISHFRY CFPFGRPEGA 780
LKATLSLLER VLMKDIATPI PAEEVKKVVR KCLEKAALIN YTRLTEYAKI EETMNQATPA 840
RKLEEVLHLA ELCIEVLQQN EEHHAEAFAW WPDLLAEHAE KFWALFTVDM DTALEAQPQD 900
SWDSFPLFQL LNNFLRNDTL LCNGKFHKHL QEIFVPLVVR YVDLMESAIA QSIHRGFEQE 960
TWQPVKNIAN SLPNVALPKV PSLPLNLPQI PSFSTPPWMA SLYESTNGST TSEDLFWKLD 1020
ALQMFVFDLH WPEQEFAHHL EQRLKLMASD MIEACVKRTR TAFELKLQKA NKTTDLRIPA 1080
SVCTMFNVLV DAKKQSTKLC ALDGGQEQQY HSKIDDLIDN TVKEIIALLV SKFVSVLEGV 1140
LSKLSRYDEG TFFSSILSFT VKAAAKYVDV PKPGMDLADT YIMFVRQNQD ILREKVNEEM 1200
YIEKLFDQWY SNSMKVICVW LADRLDLQLH IYQLKTLIKI VKKTYRDFRL QGVLEGTLNS 1260
KTYDTLHRRL TVEEATASVS EGGGLQGITM KDSDEEEEG 1299 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0045211; C:postsynaptic membrane; IDA:MGI.
 GO:0042734; C:presynaptic membrane; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0045921; P:positive regulation of exocytosis; IDA:MGI.
 GO:0016082; P:synaptic vesicle priming; IGI:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR010439; Ca-dep_secretion_activator.
 IPR014770; Munc13_1.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF06292; DUF1041 
SMART
 SM00239; C2
 SM00233; PH 
PROSITE
 PS51258; MHD1
 PS50003; PH_DOMAIN 
PRINTS