UniProt Accession

 XRCC1_HUMAN; P18887; Q6IBS4; Q9HCB1 

Genbank Protein ID

 M36089; AF512504; CR456728; AC018758; L34079; BC023593 

Genbank Nucleotide ID

 AAA63270.1; AAM34791.1; CAG33009.1; AAG09061.1; AAH23593.1 

Protein Name

 DNA repair protein XRCC1 

Protein Synonyms/Alias

 X-ray repair cross-complementing protein 1 

Gene Name

 XRCC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
129	EKRWDRVKIVCSQPY	ubiquitination	[1]
138	VCSQPYSKDSPFGLS	ubiquitination	[1]
169	SQKVTVTKLGQFRVK	ubiquitination	[1, 2]
341	FRSELRDKALELGAK	ubiquitination	[1]
369	CAFANTPKYSQVLGL	ubiquitination	[3]
618	WIYSCNEKQKLLPHQ	ubiquitination	[1]
620	YSCNEKQKLLPHQLY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. 

Sequence Annotation

 DOMAIN 315 403 BRCT 1.
 DOMAIN 538 629 BRCT 2.
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 198 198 Phosphothreonine.
 MOD_RES 199 199 Phosphoserine.
 MOD_RES 202 202 Phosphothreonine.
 MOD_RES 204 204 Phosphoserine.
 MOD_RES 211 211 Phosphotyrosine.
 MOD_RES 226 226 Phosphoserine.
 MOD_RES 241 241 Phosphoserine.
 MOD_RES 257 257 Phosphothreonine.
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 266 266 Phosphoserine.
 MOD_RES 371 371 Phosphoserine; by PRKDC.
 MOD_RES 408 408 Phosphoserine.
 MOD_RES 409 409 Phosphoserine.
 MOD_RES 410 410 Phosphoserine.
 MOD_RES 416 416 Phosphoserine.
 MOD_RES 418 418 Phosphoserine.
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 446 446 Phosphoserine.
 MOD_RES 447 447 Phosphoserine.
 MOD_RES 453 453 Phosphothreonine.
 MOD_RES 457 457 Phosphothreonine.
 MOD_RES 461 461 Phosphoserine.
 MOD_RES 485 485 Phosphoserine.
 MOD_RES 488 488 Phosphothreonine.
 MOD_RES 518 518 Phosphoserine.
 MOD_RES 519 519 Phosphothreonine.
 MOD_RES 523 523 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 633 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0006284; P:base-excision repair; TAS:Reactome.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0010033; P:response to organic substance; IEA:Compara.
 GO:0000012; P:single strand break repair; IEA:InterPro. 

Interpro

 IPR001357; BRCT_dom.
 IPR008979; Galactose-bd-like.
 IPR002706; Xrcc1_N. 

Pfam

 PF00533; BRCT
 PF01834; XRCC1_N 

SMART

 SM00292; BRCT 

PROSITE

 PS50172; BRCT 

PRINTS