| Tag | Content |
|---|
| CPLM ID | CPLM-018519 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | S-methylmethionine--homocysteine S-methyltransferase BHMT2 |
Protein Synonyms/Alias | SMM-hcy methyltransferase; Betaine--homocysteine S-methyltransferase 2 |
Gene Name | Bhmt2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 220 | WTSLQTMKLMKEGLR | ubiquitination | [1] | | 318 | FLPPASEKHGSWGSG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. |
Sequence Annotation | DOMAIN 11 305 Hcy-binding.
METAL 208 208 Zinc (By similarity).
METAL 290 290 Zinc (By similarity).
METAL 291 291 Zinc (By similarity). |
Keyword | Complete proteome; Metal-binding; Methyltransferase; Reference proteome; Transferase; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 363 AA |
Protein Sequence | MAPAGSTRAK KGILERLDSG EVVVGDSGFL FTLEKRGFVK AGLWTPEAVV EHPSAVRQLH 60
TEFLRAGADV LQTFTFSATE DNMASKWEAV NAAACDLAQE VAGGGGALVA GGICQTSLYK 120
YHKDETRIKN IFRLQLEVFA RKNVDFLIAE YFEHVEEAVW AVEVLREVGA PVAVTMCIGP 180
EGDMHDVTPG ECAVKLARAG ADIIGVNCRF GPWTSLQTMK LMKEGLRDAS LQAHLMVQCL 240
GFHTPDCGKG GFVDLPEYPF GLEPRVATRW DIQKYAREAY NLGIRYIGGC CGFEPYHIRA 300
IAEELAPERG FLPPASEKHG SWGSGLNMHT KPWIRARARR EYWENLLPAS GRPFCPSLSK 360
PDA 363 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0047150; F:betaine-homocysteine S-methyltransferase activity; IEA:EC. GO:0008898; F:homocysteine S-methyltransferase activity; ISO:MGI. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006579; P:amino-acid betaine catabolic process; IEA:UniProtKB-UniPathway. GO:0009086; P:methionine biosynthetic process; ISO:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |