CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
137RMLYSSCKSRLLDSVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Leucine-rich repeat; Membrane; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1186 AA 
Protein Sequence
XCAAPAPLTS AERELQQIRI NEVKTEISVE SKHQTLQGLA FPLQPEAQRA LQQLKQKMVN 60
YIQMKLDLER ETIELVHTEP TDVAQLPSRV PRDAARYHFF LYKHTHEGDP LESVVFIYSM 120
PGYKCSIKER MLYSSCKSRL LDSVEQDFHL EIAKKGFCRS ALHPLSLLVQ AIMLAMTLAL 180
GTLPAFLPCE LQPHGLVNCN WLFLKSVPHF SMAAPRGNVT SLSLSSNRIH HLHDSDFAHL 240
PSLRHLNLKW NCPPVGLSPM HFPCHMTIEP STFLAVPTLE ELNLSYNNIM TVPALPKSLI 300
SLSLSHTNIL MLDSASLAGL HALRFLFMDG NCYYKNPCRQ ALEVAPGALL GLGNLTHLSL 360
KYNNLTVVPR NLPSSLEYLL LSYNRIVKLA PEDLANLTAL RVLDVGGNCR RCDHAPNPCM 420
ECPRHFPQLH PDTFSHLSRL EGLVLKDSSL SWLNASWFRG LGNLRVLDLS ENFLYKCITK 480
TKAFQGLTQL RKLNLSFNYQ KRVSFAHLSL APSFGSLVAL KELDMHGIFF RSLDETTLRP 540
LARLPMLQTL RLQMNFINQA QLGIFRAFPG LRYVDLSDNR ISGASELTAT MGEADGGEKV 600
WLQPGDLAPA PVDTPSSEDF RPNCSTLNFT LDLSRNNLVT VQPEMFAQLS HLQCLRLSHN 660
CISQAVNGSQ FLPLTGLQVL DLSHNKLDLY HEHSFTELPR LEALDLSYNS QPFGMQGVGH 720
NFSFVAHLRT LRHLSLAHNN IHSQVSQQLC STSLRALDFS GNALGHMWAE GDLYLHFFQG 780
LSGLIWLDLS QNRLHTLLPQ TLRNLPKSLQ VLRLRDNYLA FFKWWSLHFL PKLEVLDLAG 840
NQLKALTNGS LPAGTRLRRL DVSCNSISFV APGFFSKAKE LRELNLSANA LKTVDHSWFG 900
PLASALQILD VSANPLHCAC GAAFMDFLLE VQAAVPGLPS RVKCGSPGQL QGLSIFAQDL 960
RLCLDEALSW DCFALSLLAV ALGLGVPMLH HLCGWDLWYC FHLCLAWLPW RGRQSGRDED 1020
ALPYDAFVVF DKTQSAVADW VYNELRGQLE ECRGRWALRL CLEERDWLPG KTLFENLWAS 1080
VYGSRKTLFV LAHTDRVSGL LRASFLLAQQ RLLEDRKDVV VLVILSPDGR RSRYVRLRQR 1140
LCRQSVLLWP HQPSGQRSFW AQLGMALTRD NHHFYNRNFC QGPTAE 1186 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0045087; P:innate immune response; IEA:InterPro.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
 GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
 GO:0050707; P:regulation of cytokine secretion; IEA:InterPro.
 GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro.
 GO:0034162; P:toll-like receptor 9 signaling pathway; IEA:InterPro. 
Interpro
 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000157; TIR_dom.
 IPR027181; TLR9. 
Pfam
 PF00241; Cofilin_ADF
 PF00560; LRR_1
 PF01582; TIR 
SMART
 SM00102; ADF
 SM00369; LRR_TYP 
PROSITE
 PS51263; ADF_H
 PS51450; LRR
 PS50104; TIR 
PRINTS