UniProt Accession

 HACD2_HUMAN; Q6Y1H2 

Genbank Protein ID

 AY191814; AK289983; AC020631; AC023165; AC025571; AC084039; BC049369; BC060839 

Genbank Nucleotide ID

 AAP20101.1; BAF82672.1; AAH49369.1; AAH60839.1 

Protein Name

 Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2 

Protein Synonyms/Alias

 3-hydroxyacyl-CoA dehydratase 2; HACD2; Protein-tyrosine phosphatase-like member B 

Gene Name

 PTPLB 

Gene Synonyms/Alias

 HACD2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	VAATAAAKGNGGGGG	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. 

Sequence Annotation

 ACT_SITE 176 176 By similarity.
 ACT_SITE 183 183 By similarity.
 MOD_RES 2 2 N-acetylalanine.
 CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).  

Keyword

 Acetylation; Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR007482; Tyr_Pase-like_PTPLA. 

Pfam

 PF04387; PTPLA 

SMART

  

PROSITE

  

PRINTS