CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat and HMG-box DNA-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 WDHD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
64CNDVINAKSICRLAWubiquitination[1]
74CRLAWQPKSGKLLAIubiquitination[1]
85LLAIPVEKSVKLYRRubiquitination[1]
88IPVEKSVKLYRRESWubiquitination[1]
186NVCDPSGKTSSSKVSubiquitination[1]
621NHLDYLAKNGYEYEEubiquitination[1]
631YEYEESTKNQATKEQubiquitination[1]
636STKNQATKEQQELLMubiquitination[1]
651KMLALSCKLEREFRCubiquitination[1]
682KYASRSRKLILAQKLubiquitination[1]
688RKLILAQKLSELAVEubiquitination[1, 2]
717EEEDFRKKLNAGYSNubiquitination[1, 3]
839NEKSPIIKPLIPKPKacetylation[4, 5]
1004KLSAFAFKQE*****acetylation[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1006 AA 
Protein Sequence
MDSSQQKTFR GHDAPVLSLS FDPKDIFLAS ASCDGSVRVW QISDQTCAIS WPLLQKCNDV 60
INAKSICRLA WQPKSGKLLA IPVEKSVKLY RRESWSHQFD LSDNFISQTL NIVTWSPCGQ 120
YLAAGSINGL IIVWNVETKD CMERVKHEKG YAICGLAWHP TCGRISYTDA EGNLGLLENV 180
CDPSGKTSSS KVSSRVEKDY NDLFDGDDMS NAGDFLNDNA VEIPSFSKGI INDDEDDEDL 240
MMASGRPRQR SHILEDDENS VDISMLKTGS SLLKEEEEDG QEGSIHNLPL VTSQRPFYDG 300
PMPTPRQKPF QSGSTPLHLT HRFMVWNSIG IIRCYNDEQD NAIDVEFHDT SIHHATHLSN 360
TLNYTIADLS HEAILLACES TDELASKLHC LHFSSWDSSK EWIIDLPQNE DIEAICLGQG 420
WAAAATSALL LRLFTIGGVQ KEVFSLAGPV VSMAGHGEQL FIVYHRGTGF DGDQCLGVQL 480
LELGKKKKQI LHGDPLPLTR KSYLAWIGFS AEGTPCYVDS EGIVRMLNRG LGNTWTPICN 540
TREHCKGKSD HYWVVGIHEN PQQLRCIPCK GSRFPPTLPR PAVAILSFKL PYCQIATEKG 600
QMEEQFWRSV IFHNHLDYLA KNGYEYEEST KNQATKEQQE LLMKMLALSC KLEREFRCVE 660
LADLMTQNAV NLAIKYASRS RKLILAQKLS ELAVEKAAEL TATQVEEEEE EEDFRKKLNA 720
GYSNTATEWS QPRFRNQVEE DAEDSGEADD EEKPEIHKPG QNSFSKSTNS SDVSAKSGAV 780
TFSSQGRVNP FKVSASSKEP AMSMNSARST NILDNMGKSS KKSTALSRTT NNEKSPIIKP 840
LIPKPKPKQA SAASYFQKRN SQTNKTEEVK EENLKNVLSE TPAICPPQNT ENQRPKTGFQ 900
MWLEENRSNI LSDNPDFSDE ADIIKEGMIR FRVLSTEERK VWANKAKGET ASEGTEAKKR 960
KRVVDESDET ENQEEKAKEN LNLSKKQKPL DFSTNQKLSA FAFKQE 1006 
Gene Ontology
 GO:0000775; C:chromosome, centromeric region; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:Compara.
 GO:0070829; P:heterochromatin maintenance; IEA:Compara.
 GO:0033044; P:regulation of chromosome organization; IEA:Compara.
 GO:0006396; P:RNA processing; IEA:Compara. 
Interpro
 IPR022100; DUF3639.
 IPR009071; HMG_box_dom.
 IPR013979; TIF_beta_prop-like.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF12341; DUF3639
 PF08662; eIF2A
 PF00505; HMG_box
 PF00400; WD40 
SMART
 SM00398; HMG
 SM00320; WD40 
PROSITE
 PS50118; HMG_BOX_2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS