| Tag | Content |
|---|
| CPLM ID | CPLM-011171 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable ATP-dependent RNA helicase DHR1 |
Protein Synonyms/Alias | DEAH box RNA helicase DHR1; Extracellular mutant protein 16 |
Gene Name | ECM16 |
Gene Synonyms/Alias | DHR1; YMR128W; YM9553.04 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | LKKKRLDKFIEHQLK | acetylation | [1] | | 116 | ERKTIIGKLQDYKID | acetylation | [1] | | 999 | SQFSKLDKFSDVFRL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis. May play a role in restructuring of the pre-rRNA. |
Sequence Annotation | DOMAIN 401 580 Helicase ATP-binding.
DOMAIN 675 858 Helicase C-terminal.
NP_BIND 414 421 ATP (By similarity).
MOTIF 516 519 DEAH box.
MOD_RES 181 181 Phosphoserine. |
Keyword | ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1267 AA |
Protein Sequence | MGTYRKRFNE KARSGHMAKL KELKRIRNKQ FTRQDENDER VENPDSAPAE SSTTEPNANA 60
EILEPLTEEE KKMKKRKLQE LFTPKESKVS RLKKKRLDKF IEHQLKREER KTIIGKLQDY 120
KIDTSLLTSS KRLGEGRQTK KEEFKEALSL ERQGRGNEQT NEILYEEYEP KVWDEYGEGG 180
SSEDDDGEDD FEASFGSMPK PTDNEEKKSS GFIDHRPAKF GGSGLSFGFS NIKVINKESK 240
TPKKKYNWRQ RVEMEELKKH GKEDEMDFDT TSEDDDEEED QEEEDKMHPS ENPLEEVESA 300
DSETGSEKFD QNDVANEFKD WANQEIKKLE GRDQELVTPT LNIDYKPIIR KEDLDDGLQE 360
AYVPINENST RKAFYVEVSR SDEIQKARIQ LPVFGEEHKI MEAIHHNDVV IICGETGSGK 420
TTQVPQFLYE AGFGAEDSPD YPGMVGITQP RRVAAVSMAE RVANELGDHG HKVGYQIRFD 480
STAKEDTKVK FMTDGVLLRE MMHDFKLTKY SSIIIDEAHE RNINTDILIG MLSRCVRLRA 540
KLHKENPIEH KKLKLIIMSA TLRVSDFSEN KTLFPIAPPV LQVDARQFPV SIHFNRRTAF 600
NYTDEAFRKT CKIHQKLPPG AILVFLTGQQ EITHMVKRLR KEFPFKKNSK YNKDLETPVS 660
KMGINSKTTD LEAEDIDFSV QVIDQDKFKS AIRYEEDEGN SGNGEDEEDE EEEGFEEVLT 720
EGQTANDPLY VLPLYSLLPT KEQMRVFQKP PQGSRLCIVA TNVAETSLTI PGVRYVVDSG 780
RSKERKYNES NGVQSFEVGW VSKASANQRS GRAGRTGPGH CYRLYSSAVF EHDFEQFSKP 840
EILRMPVESI VLQMKSMAIH NIINFPFPTP PDRVALSKAI QLLQYLGALD NKEMITEDGK 900
KMSLFPLSPR FSKMLLVSDE KACLPYIVAI VSALSVGDPF INEFELGINE ISRKPNPDEN 960
LDDKIREHDE STPGMDPELK KELRSKFYKS RSQFSKLDKF SDVFRLLSVV SAMDYVPKEQ 1020
KEIFMKKNFL RGKLMEEIVK LRKQLMYIIK SNTSKENIAV VIRNEDLKSD IPSVIQIKLL 1080
KQMICAGFVD HVAVRADVLF PDDAKITNRT SIINIPYIPV LATRTPNIED CFVYIHPTSI 1140
LNNLGEMPPK YMLYYSLHLG GNNKTRMNTL CDIASTPLAN IARKGLLLTY SKPLTGQGLK 1200
TVNLSPTERY CYVVPRFGST VDNDLKIGWD LNPIAVHQKK QKGQWTVIKF ITRKGFQTIT 1260
GEEKEKK 1267 |
Gene Ontology | GO:0030686; C:90S preribosome; IDA:SGD. GO:0005739; C:mitochondrion; IDA:SGD. GO:0005730; C:nucleolus; IDA:SGD. GO:0032040; C:small-subunit processome; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0003724; F:RNA helicase activity; IDA:SGD. GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. |
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PROSITE | |
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